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Today’s drug is rosuvastatin brand name crestor the therapeutic category is that it’s an anti-lepemic agent more specifically an hmg coa reductase inhibitor dosage form and strength the medication comes as a tablet in a five milligram 10 milligram 20 milligram and 40 milligram strength it also comes as a capsule as a sprinkle in a 5 milligram 10 milligram 20
Milligram and 40 milligram strength indications and dosing for adults the first indication is for various forms of dyslipidemia the general dosing range is between 5 and 40 milligrams by mouth every day when initiating start between 10 and 20 milligrams by mouth every day with a max of 40 milligrams per day dose adjustments are made every two to four weeks
Consider lower initiation doses of five milligrams by mouth every day in asian patients due to the risk of increased drug levels the next indication is for homozygous familial hypercholesterolemia the general dosing range is between 20 and 40 milligrams by mouth every day when initiating start at 20 milligrams by mouth every day with a max of 40 milligrams per day
Dose adjustments are made every two to four weeks consider lower initiation doses of five milligrams by mouth every day in the asian population due to the risk of increased drug levels the next indication is for cardiovascular event prevention the general dosing range is between 5 and 40 milligrams by mouth every day with similar dosing initiation adjustments and
Cautions as previously mentioned the next indication is for atherosclerotic cardiovascular disease or ascvd for short general dosing range is between 5 and 40 milligrams by mouth every day with similar dosing initiation adjustments and cautions as previously mentioned it’s best to follow the most current acc aha cholesterol guidelines when treating ascvd there
Is an off label indication for transplantation post heart or post kidney resuvastan was found to be effective in reducing cardiac allograf vasculopathy and improve long-term outcomes and reduce cardiovascular events following kidney transplantation indications and dosing for pediatrics the first indication is for heterozygous familial hypercholesterolemia for
The age range of 8 and 9 years old dosing begins at 5 to 10 milligrams by mouth every day with a max of 10 milligrams per day dose adjustments are made every four weeks consider starting at the lower end of the dosing range in asian patients the next dosing range is between 10 to 17 years of age dosing begins at 5 to 10 milligrams by mouth every day with a max
Of 20 milligrams per day dose adjustments are made every four weeks consider starting at the lower end of the dosing range in asian patients the next indication for pediatrics is homozygous familial hypercholesterolemia for the age range between 7 and 17 years old the common dose of 20 milligrams by mouth every day is used and consider five milligrams by mouth
Every day in asian patients which is that lower end of the range mechanism of action and pharmacology the mechanism of action for rosuvastatin is through the inhibition of cholesterol synthesis by inhibiting hmg-coa reductase hmg-coa reductase is the rate-limiting enzyme in cholesterol synthesis percent over a suvistan is metabolized hepatically via the sip two
C9 pathway ninety percent is excreted unchanged fecally the onset of action occurs within one week with the max effects at four weeks the time to peak in plasma is between three to five hours half-life elimination occurs in about 19 hours and rosuvastan is 88 protein bound special populations and considerations in patients with renal impairment if the creatinine
Clearance is less than 30 the initiation dose is at 5 milligrams every day with a max of 10 milligrams per day if the patient is on hemodialysis initiate the dose at 2.5 milligrams by mouth every day with a max of 10 milligrams per day in patients with hepatic impairment the medication is contraindicated if active hepatic disease or unexplained lft elevations some
Groups in which the medication is contra indicated or exercise caution is in pregnancy myopathy unexplained lft elevation alcohol abuse 65 years of age or older asian patients females of reproductive age renally and hepatically impaired diabetic and patients with hypothyroidism regarding pregnancy it should be avoided if possible discontinue use one to two months
Before conceiving in lactation the medication should be avoided when breastfeeding the drug is excreted into the milk a race consideration specific to asians is there are increased drug levels and with those increased drug levels comes a risk of toxic effects side effects some general side effects are headache myalgia abdominal pain nausea dizziness constipation
Insomnia gynecomastia cognitive impairment and the development or worsening of diabetes some general cautions are for mild memory issues and confusion some serious side effects are foamy urine which could be a serious kidney issue muscle pain tenderness weakness with fever could be a sign of rhabdomyolysis and autoimmune myopathy drug interactions some of the
Characteristics for drug interactions isro suvastan is a bcrp substrate an ntcp substrate an oatp1 1b3 and 2b1 substrate it is also gastric ph sensitive and there is also a concern for rhabdomyolysis examples of some drugs to avoid are cyclosporine phenyl fibrate and gem fibrazil some drugs to monitor or modify treatment on are atenolol bataxolol clopidogryl
Daptomyosin azenamibe and warfarin monitoring parameters a baseline should be taken for the creatinine liver function tests and creatinine phosphokinase patient counseling information rosuvastatin is used to lower bad cholesterol like ldl and triglycerides and then increase good cholesterol like hdl it is also used to slow the progress of heart disease and to
Lower the chance of heart attack and stroke if a dose is missed take it as soon as you can but if it is greater than 12 hours skip the dose some of the most common side effects are headache abdominal pain nausea joint pain and weakness it is advised to stop for a short period of time if you have uncontrolled seizures electrolyte imbalances severely low blood
Pressure severe infection or surgery or medical emergencies you
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#44: rosuvastatin (Crestor) | Dyslipidemia & Cardiovascular Event Prevention | Drug Cards Daily By Drug Cards Daily
