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People who take acetaminophen and non-steroidal anti-inflammatory drugs regularly should be aware that these drugs cause liver and kidney toxicity when taking these medications it’s a good idea to provide antioxidant support to protect the organs much of the data is derived from animal models in which nutritional interventions garnered protection against the
Acetaminophen and non-steroidal anti-inflammatory drug toxicity the specific dose studied in many of these animal models is very high when extrapolated to human equivalent doses but lower doses such as those available in nutritional products might offer antioxidant protection when used regularly in conjunction with typical doses of acetaminophen and non-steroidal
Anti-inflammatory drugs in humans sulfur-containing amino acids support the liver health following exposure to acetaminophen for those on a regime of chronic acetaminophen or non-steroidal anti-inflammatory drug use supplementing daily with sulfur-containing amino acids and other compounds to support glutathione levels might protect against drug-induced toxicity
High-dose and acetylcysteine is a conventional treatment for acetaminophen overdose it’s an effective treatment for acute liver failure due to non-acetaminophen drug toxicity also any time acetaminophen is taken at least 600 milligrams of n-acetyl cysteine should be taken alongside it to help to protect against liver toxicity methionine is an essential amino acid
Precursor to several sulfur-containing antioxidants including cysteine and glutathione and sufficient dietary methionine is necessary for maintaining the glutathione levels methionine is used as an alternative conventional antidote for acetaminophen overdose although a lack of comparative control trials makes it difficult to determine its relative efficacy to an
Acetylcysteine in some parts of the world methionine at 10 percent is included in acetaminophen products to protect against accidental intoxication a study in rats of a single tablet combination demonstrated by including the methionine it could minimize liver toxicity measured by the serum alt and ast at therapeutic doses of 100 milligrams per kg s adenosine
Or same is a methionine derivative and it’s critical for the synthesis of nucleic acids proteins and phospholipids which are compounds necessary for the recovery after acetaminophen overdose acetaminophen decreases the same levels in the nuclei and in the mitochondria of the liver cells in one study the efficacy as an antidote of same and n-acetyl cysteine were
Comparable when given to mice within one hour of an acetaminophen overdose selenium is a cofactor for enzymes that synthesize glutathione and detoxify the acetaminophen in an experimental mouse model a selenium deficiency significantly reduced the size of a lethal acetaminophen dose injecting rats with selenium 24 hours prior to the acetaminophen overdose provided
Significant protection against hepatotoxicity it lowered levels of alt and ast which are markers of liver damage and has increased the levels of glutathione oral selenium at 0.5 milligrams per kg body weight combined with n-acetyl cysteine 500 milligrams per kg body weight demonstrated a greater protective effect to the n-acetylcysteine alone when administered to
The rats within one hour of the acetaminophen overdose several carotenoids have been examined for their protection against acetaminophen overdose in rat models luton at 50 to 250 milligrams per kg per day administered seven days before an overdose preserved the glutathione levels and it reduced the elevations of alt and ast in response to the acetaminophen lycopene
Rich tomato extract five milligrams per kg per day given for seven consecutive days after an overdose had a similar protective effect single doses of beta-carotene 30 milligrams per kg or mesa zeaxanthin at 50 to 250 milligrams per kg given concurrently with a toxic acetaminophen dose reduce the serum liver enzymes and in the case of the mesozantin microscopic
Evidence of liver tissue damage silmarin is a mixture of several related polyphenolic compounds that are found in milk thistle and it promotes the detoxification by several complementary mechanisms the antioxidant capacity of the silmarin can lower oxidative stress in the liver thus associated with acetaminophen metabolism in rats this has the effect of conserving
Cellular glutathione levels like an acetylcysteine the silmarin can protect against acetaminophen toxicity furthermore an animal study suggests it might be more effective than the n-acetylcysteine for the acetaminophen toxicity if the treatment is delayed when administered to rats within 30 minutes of an experimental acetaminophen intoxication milligrams per kg of
Curcumin prevented the microscopic appearance of kidney damage it prevented elevations in renal lipid peroxidation and maintained glutathione levels comparable to the controls oral preconditioning of rats with 50 or 100 milligrams per kg per day for seven days significantly reduced the markers of liver damage the alt the ast and the lipid peroxidation following the
Experimental acetaminophen overdose the curcumin might also increase the efficacy of n-acetyl cysteine as an acetaminophen antidote with the addition of 25 milligrams per kg of curcumin to 200 milligrams per kg of n-acetyl cysteine polyphenolic antioxidants have been tested for their ability to mitigate the liver damage in mouse models of acetaminophen overdose
The pre-treatment of mice with either grape seed extract at 100 milligrams per kg per day for seven days or green tea extract 0.25 to 1 of the diet for 5 days protected the liver from the acetaminophen mediated damage as determined by the serum levels of alt and microscopic examination resveratrol at 75 milligrams per kg injected into mice one to six hours after
An acetaminophen intoxication significantly reduced the alt levels compared to the control animals in addition an injection of resveratrol at 30 milligrams per kg following the acetaminophen induced intoxication in mice resulted in reduced markers of hepatotoxicity treating rats by an injection of coq10 either before or after an acetaminophen overdose convert
Protection from liver damage the pre-treatment with intravenous coq10 at five milligrams per kg reduced the serum alt and the markers of oxidative stress but had no effect on the liver glutathione levels two injections of coq10 at 10 milligrams per kg each given one and 12 hours after an acetaminophen intoxication significantly reduced the levels of alt ast and
Inflammatory cytokines it suppressed liver peroxidation preserved glutathione and reduced tissue death high doses of a scorable planet equivalent to 600 milligrams per kg of free vitamin c given concurrently with acetaminophen prevented the elevation of the serum liver enzymes in mice and it reduced the acetaminophen mediated mortality free vitamin c ascorbic
Acid did not protect against the liver or the kidney damage in the mouse models several botanicals have been examined for protecting against the acetaminophen overdose in animal models rats were pre-treated with traditional liver tonics and drapulus peniculata and picariza cora had lower markers of liver damage of alt ast and lipid peroxidation rescue injection
Of ginkgo biloba following an acetaminophen overdose reversed the increases in serum liver enzymes lipid peroxidation and inflammatory cytokines due to the acetaminophen intoxication several compounds from garlic have been shown to preserve the liver glutathione levels as well as reduce serum markers of liver damage liver tissue death and animal mortality in
Rodent models of acetaminophen overdose when supplied in sufficient quantities up to five grams per kg of fresh garlic homogenates treatment of mice with oral melatonin at 50 or 100 milligrams per kg four or eight hours before an acetaminophen overdose suppressed the increase in the serum alt and ast activities in a dose and time-dependent manner but it had no
Effect on the liver due to pione levels when given four hours before an overdose there was marked inhibition of liver necrosis melatonin injections at 10 milligrams per kg prior to the acetaminophen overdose might be more effective than a rescue dose for reducing the liver toxicity zinc carnosine is a gastro-protective agent and it can reduce the non-steroidal
Anti-inflammatory induced gastrointestinal epithelial cell death possibly by quenching the reactive oxygen species using tracer compounds to monitor the course of the preparation in animal stomachs researchers observed the combination adhering to the stomach wall more effectively than either zinc or carnosine alone allowing the beneficial effects of both compounds
To be delivered to the site where the protection is needed a protective effect was observed in a 2007 human trial on 10 healthy volunteers taking the zinc carnosine at 37.5 milligrams twice a day and they were protected against a three-fold increase in gastrointestinal permeability caused by indo-medicine treatment licorice has been used historically in europe
As a gastroprotective ulcer healing agent the over-the-counter ulcer treatment carbon oxylone is a derivative of a naturally occurring compound in licorice a licorice decoction healed aspirin induced ulcers in the stomach of rats the healing effect was similar to two prescription treatments the proton pump inhibitor ombrazole and the synthetic prostaglandin
Misoprostol but was not effective prophylactively before the ulceration had occurred in another animal study deglycerated licorice in combination with the reflux drug cimetidine provided greater protection against aspirin-induced mucosal damage than either substance alone unlike whole licorice the glycerated licorice extracts provide gastroprotective effects
Without the glycerizin boswellic acids extracted from boswellia serrata are anti-inflammatory compounds in their own right they inhibit the activity of the pro-inflammatory enzyme 5-lipo oxygenase and they’ve demonstrated improvements in animal and human models of inflammatory diseases including asthma osteoarthritis and crohn’s disease boswellic acids might also
Protect against non-steroidal anti-inflammatory drug-induced gastric ulceration in one study rats were pre-treated with oral boswellia extract at 250 milligrams per kg demonstrated significantly less aspirin or indomethacin induced gastric ulceration determined by the qualitative determination than the control animals non-steroidal anti-inflammatory drugs are
Known to damage the gastric mucosa and contribute to conditions like ulcers when examining the mechanisms driving this another non-steroidal anti-inflammatory drug related toxicities much of the scientific community focuses on factors closely related to cox 1 and cox 2 inhibition however mitochondrial dysfunction and oxidative stress appear to also be important
Aspects of this equation several studies have shown that nutrients with antioxidant capacity might be able to mitigate the non-steroidal anti-inflammatory drug toxicity for example melatonin quercetin and curcumin have been shown to ease gastric toxicity of the non-steroidal anti-inflammatory drugs by ameliorating the oxidative stress in addition nutrients that
Support mitochondrial function like coq10 and pqq might be able to blunt some of the mitochondrial toxicity caused by the non-steroidal anti-inflammatory drugs although the hypothesis has yet to be confirmed in clinical trials more on the liver or more on herbs supplements and natural treatment plans check out my website
Transcribed from video
Acetaminophen aka Paracetamol & NSAID’s – Toxicity, Natural Prevention & Treatment By Holistic Herbalist
