January 26, 2023

In this video, Dr. Krishan Kataria summarizes clinical pharmacology and various aspects of the drug Carvedilol or Coreg. A must watch for medical students, interns, residents, doctors, nurses, nursing students, physician assistants and nurse practitioners.

Hello friends welcome to i’m exploration my name is kk and i’m a board-certified internal medicine physician in this video you will learn about carvedilol which is also known by the trade name of koreg starting with the mechanism of action coreg is a non-selective beta blocker with alpha blocking activity it does not have any intrinsic sympathomimetic activity

Correct decreases heart rate causes vasodilation increases stroke volume index it reduces cardiac output and also decreases renal vascular resistance thus lowering blood pressure moving on to the indications core egg is used in chronic stable angina except vasospastic angina core egg is used for rate control in atrial fibrillation and in patients with atrial flutter

Carbide lol is an important component of cold directed medical therapy for patients with congestive heart failure especially for those who have reduced ejection fraction it is also indicated in patients post myocardial infarction carbidiol should be avoided in hemodynamically unstable patients core egg can also be used for management of hypertension but please

Note that it’s not the first line carvadillal is also used for prophylaxis of varicel hemorrhage in patients with cirrhosis let’s test your knowledge do you know the answer to the following questions number one when used in patients with systolic congestive heart failure by what percentage can carvedilol reduce the combined risk of death or hospitalization for a

Cardiovascular reason and second question by what percentage can carvedilol reduce the duration of hospitalization in patients with congestive heart failure we will discuss the answers to these questions at the end of the presentation moving along what are some of the frequently used doses of carbadylol carbonyl all comes in two formulations immediate release tablet

And extended release capsule immediate release tablet is the most commonly used formulation in the clinical settings the dose can range from 3.125 milligram to 25 to 50 milligram twice a day extended release capsule dose ranges from 10 milligram to 80 milligram daily it should be noted that carbohydrate is available in a generic formulation thus reducing cost to

The patient let’s talk about dosing adjustments in patients with renal and hepatic dysfunction there is no need to adjust those in patients with renal dysfunction for hepatic dosing carvedilol is contraindicated in patients with severe liver impairment especially in patients with child puke class c when taken with food there is low risk of orthostatic hypotension

What are some of the common adverse effects of carvedilol as correct can reduce heart rate there is a higher risk of brady arrhythmias carvadillolol can cause bronchospasm it can cause fatigue and sleep disorder carbidylol can mask the symptoms of hypoglycemia chloric can decrease the blood pressure more than anticipated and may lead to orthostatic hypotension

What are some of the contraindications of carbide lol coreg is contraindicated in patients with decompensated congestive heart failure and in patients with cardiogenic shock for obvious reasons correct can induce bronchospasm in patients with asthma as you can imagine corex reduces heart rate and therefore should not be used in patients who have second or third

Degree av block or in patients with sick sinus syndrome harvard law should be avoided in patients with severe bradycardia one must be cautious when using carbidilololol in patients with vasospastic angina myasthenia gravis peripheral vascular disease diabetes mellitus and pheochromocytoma here we discuss some select drug drug interactions of carbodylol when used

With amiodarone it can worsen bradycardia when used with insulin and sulfonylurea correct conversion hypoglycemia when used in patients with parkinson’s disease who are on levodopa and carbidopa carfidilol can worsen the risk of hypotension please note these are only selective interactions and do not represent a comprehensive list of interactions carpet lols should

Be avoided in pregnant women and mothers who are breastfeeding let’s briefly discuss the pharmegokinetic and pharmacodynamic profile of core egg carbodylol reaches peak blood pressure lowering effect in one to two hours the half-life is 7 to 10 hours carbohydrate is extensively metabolized by liver here is one of the research studies that looked into the efficacy

Of carbodylol on the morbidity of patients with severe chronic heart failure the study is named copernicus study as you can see the study showed that carpetal all reduced the combined risk of death or hospitalization for cardiovascular disease by 27 percent and the combined risk of death or hospitalization for heart failure by staggering 31 percent patients in

Carbon law group spent 27 fewer days in the hospital for any reason and 40 percent fewer days in the hospital for heart failure were you able to answer these questions correctly are you surprised with the magnitude of benefit with carvedilol it’s an amazing drug this wraps up our discussion on carverity lol i thank you for your attention if you enjoyed learning

About car video lol please give us a thumbs up at im exploration we are building something worthwhile so please make sure to subscribe to our channel until next time we wish you all the success and happiness keep learning and keep growing

Transcribed from video
Carvedilol or Coreg: What you MUST know? By IMExploration