June 1, 2023

And it is a disease typically seen in older men that leads to prostate growth which then in turn leads to difficulty with urination. these are the four medications we’ll be discussing in this video. three of the medications are considered alpha blockers. alpha is a receptor in the sympathetic nervous system, and constrict smooth muscle in the bladder neck and prostate

Capsule, which causes retention of urine. if we block that, then we’ll relax those two muscles and then that will lead to easier urine outflow. the non-selective alpha blocker is doxazosin, or cardura. since it will also work in the bladder neck and prostate capsule, it also works in the periphery and it causes vasodilation in blood vessels, which can then also lead to

Low blood pressure. there are two selective alpha blockers that we’ll be discussing today – tamsulosin or flomax and alfuzosin or uroxatral, and those are selective for the alpha receptors in the prostate and the bladder. we can remember that they’re specific for the bladder because flomax the uroxatral, you can think of that as urine control. the other medication we’ll

Be discussing today is dutasteride or avodart and that is a 5-alpha-reductase inhibitor. 5-alpha-reductase is an enzyme that works to convert testosterone to dht, the active form of testosterone in the prostate. when we block the 5-alpha-reductase, then we have less conversion of testosterone to its active form, which then decreases the obstruction of the urethra by the

Prostate so then it will then shrink the prostate and lead to the steroid stem of dutasteride looks like steroid which can then remind you that it’s for men and kind of its that can cause abnormal ejaculation is?’ the answers for the next couple questions will remain the same, a) doxazosin is incorrect because it is a non-selective alpha blocker, and then while alfuzosin is

A selective alpha blocker, issues that tamsulosin has, so it can be a good option if men are concerned about that side effect. dutasteride has a completely different mechanism of action and it is a 5-alpha-reductase alpha blocker that can be used to treat hypertension is?’ and the correct answer is a) doxazosin. while b) and c) are both alpha blockers, they have no effect

On blood pressure since they are selective for muscles in the bladder, so those are incorrect. dutasteride is not an alpha blocker, and it does not affect blood pressure. like we discussed before, the doxazosin is not selective so it also causes vasodilation in the blood vessels so that can lower blood pressure. this can also cause some of the side effects that we see

With it, which is orthostatic hypotension, which is low blood pressure when moving from a laying to sitting or sitting to standing position. the doxazosin also has a high risk of first dose syncope, which is just passing out after you take the first dose of it your body’s not used to it. a) doxazosin is incorrect because it is a non-selective alpha blocker. there’s not

Very many drug interactions that we’re concerned about. d) dutasteride is incorrect because it is not an alpha blocker. alfuzosin is metabolized by the cyp enzymes in the liver so that can lead to a higher risk of drug interactions. if a patient is on quite a few medications that could possibly interact, this might not be a very good choice. doxazosin, tamsulosin and

Alfuzosin all work to relax urinary smooth muscles vasodilation of vessels. remember that the dutasteride looks like ‘steroid’, so it’s used in men and it inhibits 5-alpha-reductase which converts testosterone to its active form

Transcribed from video
(CC) Alpha Adrenergic Blockers Doxazosin Tamsulosin (CH 7 ENDOCRINE NAPLEX / NCLEX PHARMACOLOGY) By Tony PharmD