March 28, 2023

A detail information regarding cetirizine hydrochloride – anti-histamin drug. it includes indications, dosage regimen, mechanism of action, pharmacokinetics, overdosage, side effects, counselling for patients.

Hello everyone welcome to drugs in detail today our topic is sweat present hydrochloride it is used as antihistamine it is a otc medication used for allergy coming to its availability sweat vision is available in both tablets and share up in tablets form it is available as 5 and 10 mg and as sit up it is available as 5 mg per 5 ml which comes in 120 ml and

Coming to indications citron is mostly used for seasonal allergic rhinitis the symptoms of this disease are sneezing rhinoria nasal burritis ocular pruritis tearing and redness of eye and it is seasonal as same there is an other disease which is perennial allergic rhinitis which means it will be along the ear the symptoms of perennial allergic rhinitis are

Also same as seasonalistic finer dish and it is also used for chronic utric area the symptoms are uncomplicated skin rashes and they also have hives which are dotted red colored spots on the skin it is used in six months of age or older coming to mechanism of action it is an h1 receptor antagonist h1 receptor is histamine receptor h1 receptor is present in

Peripheral regions which are respiratory smooth muscle vascular vascular endothelial cells immune cells and gastrointestinal tract these block histamine receptors and they cause vasoconstriction sorry here it is bronchodilation an anti-inflammatory effect coming to pharmacokinetics of citrogen absorption after intake of tablet the peak plasma concentration

Reaches in one hour and distribution 93 of drug binds to protein and metabolism saturation is converted into metabolite by oxidative or the alkylation the metabolites doesn’t have any significant effect coming to elimination 70 percent excreting urine and 10 percent in fishes dosage and administration adults and children who are 128 or older 5 to 10 mg per

Day once daily and children 6 to 11 each 5 to 10 mg straight up once daily the syrup is 5 mg per 5 ml so 1 or 2 teaspoon one two teaspoon is equal to five ml and in children aged between two to five each 2.5 mg it means half teaspoon maximum is 5 mg once daily or 2.5 mg twice daily and in children 6 months to less than 2 yet maximum dose is 5 g 2.5 mg

Twice daily or 2.5 mg once daily coming to overdosage the symptoms of overdose are restlessness irritability and drowsiness there is no antidote for said regime and it is not effectively removed by dialysis only 10 percent of drug is removed by dialysis coming to special population it is pregnancy category b drag there are no human data available and it

Excretes in milk of matching women in both pregnancy and nurturing women it should be used depend on benefit and risk ratio and in renal impairment in moderate severe and hemodialysis patients there is decrease of clearance seventy percent decrease in clearance and in hepatic impairment there is forty percent decrease in clearance in both renal and hepatic

Impairment patients maximum dose is 5 mg and in geriatric population greater than 75 years clearance decreases it may be attributable to decrease in renal function dosage should be choosed cautiously in geriatric population coming to side effects it is categorized based on age 12 year or older patients more side effects are somnolescence it is kind of

Excessive sleepiness want to sleep kind of fatigue dry mouth and pharyngitis an impatient six to eleven year old headache pharyngitis and abdominal pain and coughing coming to interactions there are no significant interactions with citrus and it does not induce or inhibit cytochrome enzymes when citizen is given with theophylline at a dose of 400 mg once daily

Of theophylline some studies shows that it is there is a decreased clearance of tetragen contraindications patients who are hypersensitive to cytorexine and also who are hypersensitive to hydroxyzine hydrocasin is first generation antihistamine the metabolite of hydroxyzine is saturation patient should not take along with alcohol or cns depressants as it

May induce excessive drowsiness coming to counseling points patients should not take alcohol and they can take saturation tablet with or without food they should be alert while operating heavy machinery or driving vehicles thank you so much for watching hope everyone understand well please like share and subscribe direction detail

Transcribed from video