February 8, 2023

In this episode of Drug Talk, I discuss a medication from the benzodiazapine class known as Clonazepam.

Hey everybody welcome back to another episode of drunk talk as always i’m your host garrett campbell today we’re gonna be talking about a medication known as clonazepam very similar to a medication lorazepam that we talked about in a previous episode before we get started just keep in mind as always that this channel is used for information purposes only and

It’s not meant to be a source of recommendations for your personal health care so as i mentioned clonazepam does fall in the class of a benzodiazepine these are typically known as being used for anxiety but each medication in this class does have different indications this one is commonly seen in seizure disorder for example so benzodiazepines in general bind to

Benzodiazepine receptors in the body which act as a specific binding site for gaba which is the gamma-aminobutyric acid neurotransmitter this neurotransmitter is the main inhibitory neurotransmitter in the cns before an individual was to use clonazepam there are a couple contraindications or reasons the medication should not be used that should be that they should

Be made aware of so it should not be used in individuals who have my athenian gravis and should also be avoided in individuals of closed angle glaucoma but it may be used in patients who are receiving appropriate therapy for open-angle glaucoma these two contraindications are more specific to the benzodiazepine class in general there may be added contraindications

For clonazepam specifically and you would just consult the drug monograph to find the zone asides and contraindications there are also some precautions that should be taken when using this medication elderly or debilitated patients patients with low serum albumin and patients with liver disease seem to experience the most cns side effects to minimize the effect

Of ataxia dizziness and / sedation it’s often recommended that people start this medication on a very low dose and slowly increase it to again the lowest possible dose that will help them with their symptoms benzodiazepines in general can produce prolonged cns depression in neonates they lack the ability to convert the drug to its inactive metabolites in the

Body and reversible dementia has been detected in elderly patients on a longer course of benzodiazepines when comparing short-acting benzodiazepines to long-acting benzodiazepines it seems that the long-acting class has a greater risk to elderly patients in terms of falls which could lead to things such as hip fractures and hospitalizations therefore we should

Generally try to avoid long-acting benzodiazepines for the elderly patients in this population it’s very important to individualize the medication therapy and and also individualize the monitoring plan because some people will need increased monitoring serious behavioral changes and abnormal thinking have been reported with benzodiazepine use these could even

Go as far as hallucinations and lastly because of some isolated reports of blood disc ratios and abnormal liver function tests it isn’t a bad idea to get liver function tests done and some blood work if you’re on a long term benzodiazepine in terms of dosage of clonazepam for anxiety and panic disorders we often see 0.25 milligrams to 0.5 milligrams taken twice

A day and for seizure disorder we often see a dose of 0.5 milligrams taken 3 times a day and then that dose could be increased by 0.5 milligrams or one milligram every three days until an appropriate dose is reached the maximum dose in this case again talking the seizure disorders would be 20 milligrams a day after the dosage of clonazepam is taken it reaches

Its peak concentration in your bloodstream at about 1 to 2 hours post dose and a half life of clonazepam or the time it takes for the concentration in your bloodstream to decrease by half is 20 to 80 hours in terms of side-effects the most common with clonazepam our dose dependent cns effects so this could be hallucination over sedation general fatigue or just

Something as simple as lightheadedness the fatigue that most people experience could potentially decrease over time if you are using the medication consistently but oftentimes people will experience that fatigue some serious side effects but not too common side effects are hypersensitivity reactions mental depression behavioral disorders jaundice or hypotension

Memory impairment or a venous thrombosis some side effects that have come up from time to time but are very very rare are abdominal or stomach cramps blurred vision constipation diarrhea or some sexual dysfunction if somebody developed impaired coordination or lethargy diminished reflexes or confusion they could possibly be experiencing an overdose and should be

Taken to the emergency room to be checked out that’s all we’re going to talk about here today with clonazepam i apologize for lighting and whatnot in this new room i just kind of put together i’ll try to get it set up better for the next video keep in mind as always like i mentioned at the start of the video all videos are just for information purposes only don’t

Use these videos as a source of a recommendation for your personal healthcare and if you like the videos and want to help see the channel grow you can like the videos or share the videos don’t be afraid to leave a comment if you’d like to request a medication in the future that’s all for today take care

Transcribed from video