March 24, 2023

Pharmacist review of the side effects of Clopidogrel (Plavix), drug interactions and uses of Clopidogrel.

Hello folks welcome if you’re new around here my name is kwai ku and i am a pharmacist on this channel i do medication reviews and talk about interest in health care topics if this is something you find interesting please consider subscribing and i’ll be more than honored to have you as a subscriber today we’ll be reviewing the medication clopidogrel which is also

Marketed under the brand name plavix we’ll take a look at that description and uses we will look at the dosing some side effects as well as some common drug interactions that you should be aware of and all these topics i’m gonna have links to them in the description such that if it is only one area that you’re interested in just the side effects there’ll be a link

In the description you just click on that time stamp and it will take you directly to the side effects or whatever you want to watch so feel free to move around as you please just a little disclaimer though that this review is just for informational purposes and is not intended to be a substitute for medical advice from your physician so clopidogrel or plavix at

It is known by its brand name is a medication that is used to prevent tram buses or for the prophylaxis of tram boces not rhambo so simply means their formation for blood clots there are certain people who are the relatively higher risk of developing blood clots and such people benefit from clopidogrel such people include people who’ve had a recent heart attack or

Myocardial infraction people who’ve had a cerebral vascular accident or stroke or any other vascular incidents for that matter or some people may have some irregular heartbeats which kind of increases their risks of developing blood clots so clopidogrel is referred to as a platelet inhibitor meaning that it prevents your platelets from aggregating to get no platelet

Aggregation is the means by which blood clots are formed so if you’re able to prevent this process then the people that i mentioned earlier who are a relatively higher risk of developing such blood clots they get protection or they’re protected the maintenance dose for clopidogrel is typically 75 milligrams taking daily however it is not unusual to see what is

Called a loading dose where you are giving a relatively high dose sometimes through milligrams of 600 milligrams of chloral once this usually brings the level of clopidogrel in the blood to an appreciable level and then maintenance dose is continued from there with respect to side-effects clopidogrel is generally well tolerated a lot of people take it without any

Issues or without any serious side effects some common side effects include bruising diarrhea stomach pain and even constipation has been reported in some instances these generally tend to go away b another serious ones the more serious side effects of epidural have to do with bleeding either in the gut in the ice or in the brain now this type of bleeding tends

To be relatively rare but it is serious and therefore if you notice any of the following symptoms it will be definitely be a good idea to reach out to your doctor right away a bloody or black tarry stools red or dark brown urine spitting up blood or brown material that looks like coffee grounds red spots on the skin unusual bruising or bleeding from the eyes the

Gums or the nose now these are generally indicative of norris or a serious problem that needs to be taken care of right away so like i said earlier please do seek medical attention if you notice any of these now with respect to drug interactions there are certain medications that reduce the efficacy or the antiplatelet activity of clopidogrel typical example is

Calcium channel blockers like amlodipine and proton pump inhibitors like omeprazole which is used for acid reflux what happens is that clopidogrel is converted into what is called an active metabolite in the body for it to be active and this depends on setting enzymes what some of these do like on my resolve inhibits the enzyme that converts clopidogrel into

Its active metabolite and therefore in the presence of a map resolve there’s a very high chance that what petrol girl may not be as effective as it was intended so definitely let your doctor know if you’re taking any of these medications so appropriate measures can be taken there are also the other set of medications that actually increase the risk of bleeding

So obviously a medication like warfarin or coumadin will be toppled if you’re ever taking them concurrently risks of bleeding increases significantly also nsaids like ibuprofen naproxen they all increase their risk of bleeding so it would definitely be a good idea to let your doctor know now clopidogrel may be given with aspirin in setting instances while this

Is would solely depend on your individual conditions just bear in mind that that combination may increase your risk for bleeding therefore you definitely take all the necessary precautions and be on the lookout for any signs of bleeding especially internal bleeding the ones that we discussed earlier another class of medications that when used concurrently with

Clopidogrel increases your risks of bleeding include setting antidepressant medications the classes the s and our eyes and the ssris now these include things like duloxetine or cymbalta venlafaxine or fx a– zoloft or settling paxil or paroxetine and a few others so with these us we’ll just be on the lookout for any signs of bleeding and report it to your doctor

Immediately i thank you for watching i hope you found the video useful if your data please give it a thumbs up and if you have not already subscribed please consider doing so thank you so very much and catch you on the next one

Transcribed from video
Clopidogrel Side Effects, Drug Interactions and Uses | Plavix Side Effects By Pharmacist Conversations