May 29, 2023

This video was made by Patricia De Perio, 2023 Pharmacist Candidate. She will review: Patient consultation points, indications, dosing and adjustments, mechanism of action, side effects, and monitoring parameters

Hello everyone my name is patricia de perio and i’m a student pharmacist class of 2023 and today i will be talking about diloxetene or the brand name cymbalta first i’ll be going over some patient counseling points what it’s used for how to take it and just some common side effects that you may experience when you start taking this drug so savalta can be used for

Many different things this includes depression anxiety it can also be used to help with painful nerve disease and diabetic nerve problems some patients use it to ease long-term pain problems or to treat fibromyalgia this drug is best taken with or without food make sure to swallow the capsule whole but if you’re unable to swallow you may sprinkle the contents

On applesauce and swallow the mixture right away without chewing as we know all drugs may cause side effects however many people don’t experience any side effects or may have some or if they do it’s only minor side effects the most common side effects patients may experience are going to be headache dry mouth trouble sleeping you might also feel a little

Dizzy sleepy tired or weak and this drug has also shown that patients experience decreased libido don’t stop taking this drug all of a sudden without calling your doctor you may have a greater risk of side effects but if these side effects bother you or won’t go away definitely call your doctor to see if there are any alternative medication to replace it with

Even though it may be rare some people may have very bad and sometimes deadly side effects when taking a drug tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect this includes signs of allergic reaction or signs of bleeding like throwing up or coughing up blood signs of

Low sodium levels like headache seizures or changes in balance trouble passing urine liver problems have happened with this drug as well it’s rare but it’s very deadly so call your doctor right away if you have any signs of liver problems like dark urine feeling tired not hungry light colored stools or yellow skin or eyes and drugs like this one have raised

The chances of suicidal thoughts or actions in children and young adults the risk may be greater and people who have had these thoughts or actions in the past all people who take this drug need to be watched closely call the doctor right away if signs like low mood nervousness restlessness or any changes in mood or actions that are new or worse now let’s talk

More in depth about symbalta deloxetine or cymbalta belongs to the drug class called serotonin and norepinephrine reuptake inhibitor or snris it’s an oral antidepressant drug indicated for the following conditions such as major depressive disorder in adults generalized anxiety disorder in adults and pediatrics diabetic peripheral neuropathic pain in adults

Fibromyalgia in adults and pediatrics and chronic musculoskeletal pain in adults how the way snris work is by binding to the serotonin and norepinephrine transporters and inhibiting them leading to increased levels of these neurotransmitters within their synaptic cleft this helps improve symptoms of depression and may also be useful in other conditions like

Anxiety and neuropathic pain for dosage and formulation symbolta comes in a delayed release capsule it’s available as a 20 milligrams 30 milligrams in a 60 milligram capsule and for dosing it depends on the patient’s indication as well as age so the starting dose differ as well as the target dosing these dosages are available on the table provided so for example

For generalized anxiety disorder the starting dose for adults is 60 milligrams a day before geriatrics it’s 30 milligrams and then for pediatrics it also starts as 30 milligrams a day and then their target dose is 60 milligrams for adults and then for geriatrics you want to increase it to up to 60 milligrams and then pediatrics it ranges to 30 to 60 milligrams a

Day and if a provider wants to discontinue this drug you want to gradually reduce the dosage to avoid discontinuation symptoms for drug interaction symbol is contraindicated with the concomitant use of an maois amigos or monoamine oxidase inhibitor is another class of antidepressants the four most commonly prescribed miois are saladulene isocarboxacid phenylzene

And genocipromine avoid the use of some malta within 14 days of stopping an maoi and also zymbalta is contraindicated when using lynasaline or iv methylene blue zymbalta interacts with potent inhibitors of sip1a2 which should be avoided examples of sip 1a2 includes clozapine lanzapine fl voxamine haloperidol and theophylline and potent inhibitors of c sub

2 d6 including bupropion fluoxetine paroxetine quinidine and terbinifene should be avoided as well as it may increase symbolic concentrations and for consideration zimbata is a moderate inhibitor of sip2d6 as well now for some adverse events for cybalta just some common side effects that patients may experience usually pediatric patients experience decreased

Weight decreased appetite nausea vomiting fatigue and diarrhea and then for adults they usually experience nausea dry mouth somnolence constipation decreased appetite and hyperhidrosis and then warnings and cautions that is where but they patients may experience are hepatotoxicity orthostatic hypotension serotonin syndrome increased risk of bleeding severe

Skin reaction activation of mania or hypomania glaucoma and seizures for specific populations zymbalta should be avoided in patients with chronic liver disease or cirrhosis and with renal impairment avoid use in patients with severe renal impairment when they have a gfr of less than 30 milliliters per minute for pregnancy this drug may cause harm to the unborn

Baby if you take it while you are pregnant if you’re pregnant or you get pregnant while taking this drug call your doctor right away in the third trimester of pregnancy it may the usage of somebody may lead to some health problems in the newborn and tell your doctor if you are breastfeeding or plan to breastfeed as this drug passes into breast milk and may harm

Your baby monitor for sedation poor feeding and poor weight gain in units here are my reference thank you everyone and have a great day

Transcribed from video
Cymbalta-Duloxetine Drug Informational Video By Riverside Rx Services