February 8, 2023

Come learn about how serotonin upsets your tummy.

Hello my name is laura wit and my presentation is over a citalopram and the and its effects within the nervous and digestive systems so i chose to do my research over an ssri in this case a citalopram due to the work i do with in a children’s behavioral health hospital um sorry really just interested to better understand how a popular ssri works not only within

Our brain but why it elicits side-effects elsewhere in the body as well so as appel prim is an antidepressant within within the class of psychotropic drugs called selective serotonin reuptake inhibitors um a comes by its generic name lexapro and is often used to treat anxiety disorders major depression ptsd psychosis and even mood disorders sfl prim is actually

The daughter medication to the ssri citalopram so in other words it’s the structural isomer to citalopram which basically means that they have the same molecular structure but that they carry out different chemical behaviors and reactions so basically a citalopram was created succeeding citalopram because it was supposed to be even more selective and therefore

More efficient and having less adverse side effects so is atop rim and other ssris were developed in response to the serotonin hypothesis of depression which basically argues that depression and anxiety are caused by imbalanced orphis specifically low serotonin levels in the brain and that increasing serotonin levels would fix this imbalance and bring emotional

Regularity so to better understand the effects of escitalopram we need to know how serotonin works in our bodies serotonin which is otherwise known as its fancy scientific name 5-hydroxytryptamine um is a narrow transmitter or sometimes even referred to as a hormone or thought of as one it’s involved in the intensity and transmission of signals from neurons to

Neurons and thus stimulating brain structures like the hypothalamus and thalamus in others that control our sleep cycle behaviors emotions and even memory um so this picture just shows the pathway of serotonin through the brain so as you can see serotonin is mostly dispersed from the brainstem and then it’s delivered through important brain structures such as

The amygdala um in others and eventually goes to the various other lobes throughout the brain so a citalopram within the central nervous system so the mechanism of escitalopram within the central nervous system is to block the reabsorption of serotonin from the synaptic cleft back into the presynaptic cliff so this increases and prolongs the availability of

Serotonin within the saina and within the synapse and supposedly it’s connected to improved signal transmission and connections between the hypothalamus and the thalamus and inevitably leads to emotional and chemical homeostasis in the brain allegedly so so here’s a short video sort of demonstrating accessorize work by inhibiting a mechanism called reuptake in

Reuptake a protein called a transporter transports excess neurotransmitter molecules out of the synaptic cleft usually back into the neuron that released them ssris inhibit the reuptake of serotonin by inhibiting the removal of serotonin from the synaptic cleft this causes levels of serotonin in the synaptic cleft to rise these increases in serotonin levels have

Been hypothesized to be the mechanism by which ssris can treat in terms of a depression okay so serotonins role within the digestive system so it’s a towel pram and other ssris are known for unfortunately coming with some side effects such as nausea and stomach issues and i wanted to know why does this happen well the lining of our digestive tract and between

The intestinal villi holds important structures called inter chromatin cells or ec cells so these cells fire synthesize and secrete serotonin into our gi tract in fact 95 percent of serotonin recites here which is pretty crazy so serotonin actually plays a very important role in the digestive system such as regulating gut motility stimulating gastric secretions

Stimulating peristalsis contractions and it’s even responsible for perception of nausea and the stimulation of vomiting um so this picture shows an easy sell than synthesizing a molecule of serotonin or 5ht which then triggers such such functions as secretion absorption and digestive reflexes all right so a citalopram in our digestive system so how does an ssri

Like escitalopram affect the digestive system well some research argues that the inhibition of serotonin reuptake by escitalopram increases the action of serotonin on its auto receptors in the gi tract and the central nervous system so they suggest that this over stimulation on these recep’s receptors can trigger such digestive issues like nausea and acid reflux

And diarrhea but contrary other research argues that appropriate doses of s of tau cram so ones that are not too high could actually bounce serotonin levels and improve digestive function so basically the significance of this is just that the effects of the escitalopram in its product serotonin within different organ systems like our digestive and nervous systems

Demonstrates their complex relationship and communications that occur within the different systems of our body and finally i have this picture which just shows the gut brain access relationship how intestinal microbiota influenced printing behavior and how it accordingly influences intestinal microbiota and then in that bottom left photo we have this foreign bacteria

Or normal bacteria sometimes and it triggers our ec cells to then by opens synthesize serotonin which is absorbed in platelets within our blood and then increases the stimulation of neurons in our body and here are my references so thank you hope you learned something

Transcribed from video
Escitalopram and Its effects within the Nervous and Digestive Systems By Laura Witt