January 26, 2023

Fluoxetine Case Study Challenge

Depression is a highly common mood disorder caused by abnormal activity in the brain it is characterized by a persistent feeling of sadness loss of interest and can interfere with daily living there are six most common types of depression in america including major depressive disorder persistent depressive disorder bipolar disorder seasonal depression postpartum

Depression and psychotic depression an estimated 16 point 2 million adults in the united states had at least one major depressive episode this number represented 6.7 percent of all us adults depression is one of the most prevalent mental illnesses in the united states seventeen percent of us adults have lifetime prevalence the prevalence of depression in women is

More common than event the causes of depression have been associated with chemical imbalances of neurotransmitters in the brain including dopamine norepinephrine and serotonin scientists have identified that variations and genes called polymorphisms can predispose people to depression one example of these polymorphisms that affects serotonin production is changes in

The hypothalamic-pituitary-adrenal or hpa axis changes in the hpa axis can affect the ability of tryptophan to gain access to the central nervous system serotonin is a monoamine neurotransmitter tryptophan is an amino acid precursor of serotonin tryptophan is converted to 5-hydroxytryptophan or 5-htp 5-htp is unconverted to 5hd also known as serotonin low serotonin

Levels have been linked to depression it is believed to help regulate mood social behavior appetite digestion sleep and memory there are a variety of options for treatment of depression including medication psychotherapy increasing exercise changing diet and so on but the treatment we’ll be focusing on is antidepressant medication specifically selective serotonin

Reuptake inhibitors or ssris the specific ssri that we’ll be looking at is fluoxetine also known as prozac it’s used to treat depression ocd bulimia and panic disorder we will discuss the l’occitane mechanism of action in the brain and how it affects there we take serotonin travels through the neurons of the body two channels and attached to your acceptors of the

Postsynaptic down the binding of serotonin said signals that regulate would these channels are reversible and serotonin is able to travel back through the presynaptic neuron the excess reuptake of serotonin through the channels is what can meet – depression fluoxetine is a small chiral molecule blocks team and other ssris bind to the serotonin transporter channel

On the presynaptic neuron this disables the gating mechanism of the transporter channel which means it is no longer able to transport serotonin serotonin is denied reuptake or blocked while going back through the channel this results in serotonin staying in the synapse between the neurons for a longer period of time and allows for more binding of serotonin to

Serotonin receptors the more serotonin binds to the serotonin receptors the more significant the antidepressant effects of the last teen are a small red molecule is fluoxetine binding with the serotonin transporter protein leucine t through van der waals forces fluoxetine has an amine group and three fluorines that create an electronic dipole moment which allows

For binding with leucine teeth so oxygen and other ssris have proven to be successful in treating depression yet fewer than 50% of people receive treatment this is an important issue because depression affects many people worldwide an untreated depression is the number one cause of suicide freshner is responsible for 850,000 deaths every year suicide is the third

Leading cause of death for individuals between the ages of 15 and 24 in the past six years there has been a 56% increase in the number of college students reporting depression symptoms if you or someone you know is experiencing suicidal thoughts please call the suicide hotline number to get the help that you need you

Transcribed from video
Fluoxetine By Ashley Meyer