February 8, 2023

Glipizide is a prescription medication used to treat Type 2 Diabetes. In this video I cover how it’s dosed, side effects plus give you my overall take on this medication towards the end of the video.

Hey this pharmacist curtis alexander in this video i’m going to be going over glippazide which is a diabetes medication and just kind of giving you an overview from the dosing to what it’s used for some of those other things side effects warning and so on and so forth at the end i’ll kind of give you my overall view of it so i want to hop right into it um as we

Kind of talked about it’s diabetes medication but it can only be used in type 2 diabetes which means you still have a functioning pancreas um what it does in your body so there’s a few things going on number one it’s it’s in a class of drugs called a cephal urea and what they do they essentially go to your pancreas and they stimulate the beta cells in the pancreas

To release insulin what also happens is we see a decrease in the amount of glucose that’s released from your liver and finally we can see some increased insulin sensitivity in the periphery of your body the the outside of your body so those that’s essentially what uh glyphozite is doing now as far as dosing you’re going to see different dosing recommendations

I always recommend with glipozide start out with the lowest dose possible which is two and a half milligram uh in most cases that’s a safe dose to start with so two and a half some people will start at five milligrams a day and this is for the immediate release formulation um and you want to take that about a half hour before meals with the immediate release you

Can increase it by two and a half to five milligrams every four weeks it really depends on how you’re doing i again i always like to see people stay at the lowest possible effective dose and i’ll get into why here in a second uh max dose is 20 milligrams a day most people’s standards and then there’s also an er formulation so when you get up to say 10 milligrams

A total daily dose of the ir you may be doing 5 milligrams morning 5 milligrams evening with the er formulation it’s always once a day two and a half to five milligrams daily you take it with the first meal to start out increase slowly the er formulation is generally a good one if you’re somebody who’s diabetic and your sugars aren’t completely out of control if

They’re fairly close to goal er would be a decent starting point if you wanted to switch either way you just take your total daily dose so you know if you’re taking 10 milligrams daily so 5 milligrams twice a day of the ir you could just go to 10 milligrams once a day so that’s how you switch now let’s get into the warnings and side effects because there’s a few

Of them with glyphoside first and foremost and this is controversial sulfa allergies so you’ll have people come in and go okay glyphosate’s a sulfonylurea i have a sulfa allergy i can’t take it right and the general consensus is that we need to be very cautious with those folks but what we find is if somebody had an allergy to say a sulfa antibiotic the cross

Reactivity the chances of reacting to glyphoside which is not an antibiotic is fairly low so there are some doctors that don’t worry about it some pharmacists don’t worry about it others do i tend to be more on the cautious side if you have a sulfa allergy i would be very very careful but the evidence is kind of conflicting so i just wanted to throw that out

There obviously the main side effect we’re worried about is blood sugars going too low remember we’re releasing more insulin we can see sugars go low it doesn’t happen frequently we see this around three percent of folks but something you want to be concerned about the people who are at the biggest risk you have to be careful how much food you’re eating if you’re

In an extreme deficit if you’re trying to diet and crank and way back on the calories that can put you at higher risk uh prolonged exercise if you’re a runner a marathoner something to be careful of drinking alcohol is a risk factor so is your age we see the hypoglycemia the low blood sugars more in the elderly population certain beta blockers can increase the

Risk of this hypoglycemia and that kind of ties into some pathomimetic agents basically these are medications that cause your sympathetic nervous system to kick in so hypoglycemia is the main side effect we’re worried about what are some other warnings and side effects a lot of people nowadays have had bariatric surgery stomach stapling those sorts of things we

Have to be really careful because it changes the absorption pattern and we can see again it ties back into the hypoglycemia but really should be a risk factor for hypoglycemia you can take it during pregnancy but most recommendations stayed stop it two weeks prior because we can see in moms who take liposide right up to delivery we can see hypoglycemia in the

Infant after the infant is born so it’s something most of the time they’re going to have you stop a couple weeks prior to giving birth cardiovascular disease another controversial one some studies show that you can see an increase in cardiovascular mortality versus um versus just a diet or diet and insulin the problem with this is there’s conflicting evidence

So that’s something obviously you’re gonna have to talk to your doctor about i just put it out there to be on the safe side and to let you know now as far as kind of some of the more rather than warnings but some of the side effects we see diarrhea is not uncommon one to five percent nervousness and tremor around four percent um dizziness we can see two to seven

Percent funnily enough funnily i don’t even know if that’s word it is here constipation three percent you can also see diarrhea so people are always like well why can i see two different things we don’t know i mean that’s one of the things about medications they think it’s uh always scientific and we don’t always have the explanations but you can see either or so

My overall thoughts as a pharmacist on glyphoside not usually the first line therapy most people are going to start with metformin which uh i think i did a video on metformin i’ll post it in the description um but for folks who’ve tried failed metformin are not quite getting the results clepozide is maybe a next best step um we have a lot of different dosages we

Can kind of um you know get the right dose for for different patients um there’s some risks though i mean most of the time we can manage the low blood sugars most of the time if we start low enough go slow enough we can manage the blood sugars the biggest thing is as a diabetic i’m just going to be really frank here most diabetic patients who i see getting

Medications do not have their diet on point they’re either following these wacky extreme diets or they’re just not eaten very healthy meaning a lot of processed garbage and so yeah glyphoside these medications can help but only as much as your diet is dialed in and your lifestyle style then so anyway if you’ve taken glyphoside if you know somebody who’s taking

Glyphoside what were the results did it help did you experience side effects post it in the comments it’s helpful for me it’s all helpful for other people who watch the video okay so i hope this video was helpful and until the next one i will see you thanks

Transcribed from video
Glipizide Review: Uses, Dosing, Side Effects + Pro's and Cons By Curtis Alexander Pharm.D.