March 28, 2023

Oliver Grottke, MD of RWTH University Hospital in Germany discusses his abstract presented at ISTH 2015, which investigated the impact of idarucizumab in reversing continuous bleeding. Following an induced injury in dabigatran-anticoagulated animals, the investigators found that a first dose of idarucizumab immediately following the injury significantly reduced blood loss, however following a 2nd injury 1 hour later and the subsequent administration of placebo, bleeding restarted. With a split idarucizumab dosing approach (60mg/60 mg) following a 1st and 2nd injury, the investigators found a significant reduction in bleeding following both traumas, implying full reversal after the second reversal. Antidotes such as idarucizumab are an important new tool in anticoagulated patients following poly-trauma.

Thrombosis tv thomas baldrick here at the 2015 is th conference in toronto joined now by dr. oliver groggy from our w th university hospital in germany thanks for coming all the way here just to do this thank you very much it’s a great present honor to be here all right so you’ve got an abstract here but tell us about what research you’re presenting and why you

Chose to do this while i was investigating over the last two and a half years there was a to map which is the specific antidote fragment to the bigger town in several models experimental models of bleeding to see the impact of fully anti-correlated organisms followed by severe trauma investigated the impact potentially reducing blood loss when we use it there was

It some up so the study that i presented here was one part of this whole study which was primarily interest in looking at one we have continuous bleeding under anticoagulation following a first off of it there is it some up giving a second tooth off it errors its mob one hour later and we actually looked at three different juices and of it there was it smell in

This setting and what were the key findings that you discovered well we saw that we have first of all in our animals which of course are all on easter sized and bambi induce this blunt liver injury and including also be lateral femoral fracture or after anticoagulation was dabigatran we found that if we give a first dose of 60 milligrams of it arizona mob we see

Immediately significant reduction in blood loss but then again after a second that was the first injury we performed the second one after one hour and we found if we give new either results him up but only placebo then that the bleeding started again and this was due to the fact that the dabigatran levels which were initially neutralized came back after the second

Trauma when we use the split juice in a different group 60 and 60 milligrams per kg dara’s it’s a mob we found a significant reduction but after first and also after the second trauma which means and plies that fully reversal then after the second juice of it errors it’s a mob and the the second trauma we could see that this proved a hundred percent of survival

And which was caused by fully neutralization after we got on anticoagulation in your opinion why is it important to have an antidote for dabigatran well as was air all the anticoagulants you want to anti correlate your patient and if you had an emergency situation like polly traumatized patient’s following a car accident and whatsoever being on an anticoagulant

You want to have if you bring your patient in the hospital immediately be versal off your anticoagulant to prevent further bleeding on that and that’s why i think it’s important to have one specific antidote who are the types of patients that would benefit if this agent is approved well it’s obviously the patients that come in hospital and which needs immediately

Reversal so for instance patients which have severe massive life-threatening bleeding including polly traumatized patients patients with intracranial hemorrhage for instance they are those patient that immediately need any reversal off their anticoagulant if we have patients which do not require urgent surgery for instance which can be delighted for 12 or 24 hours

You obviously just can wait till until the effects of your anticoagulants are gone but it’s really specifically for the patient that come in need immediately procedure where there’s no time actually to wait till your anticoagulant of facts get off okay nicely done dr. rocky thanks for coming by and sharing your work with us thank you very much was a pleasure

Transcribed from video
Idarucizumab Reversal of Bleeding in Dabigatran-Anticoagulated Animals By Thrombosis.TV