June 4, 2023

In this episode, I discuss a medication known as indapamide (Lozol).

Everybody welcome back to drug talk as always i’m your host garrett campbell today we’re gonna be discussing the medication known as in damage its brand name is loza now before i talk about the medication itself just keep in mind that this channel is for information purposes only and not to be used as a source for recommendations for your personal healthcare so in

Depth light is a medication that’s used for hypertension or high blood pressure its mechanism of action is not completely understood however it’s presumed that it has renal as well as extra rino effects specifically it’s anti hypertensive action is thought to be caused by a reduction in peripheral vascular resistance in terms of its diuretic effects it inhibits

The reabsorption of water as well as electrolytes primarily as a result of its action on the distal tubules of indications for use i did mention that in dap amide is indicated to be used in the treatment of hypertension or high blood pressure and it can also be used to treat edema associated with congestive heart failure now before somebody was to use in dab

Amide or lowes all there are some contraindications that they must clear as well as the precautions and warnings that they should be made aware of it will be contraindicated in patients who have a hypersensitivity to indium i’d or to other sulfonamide derived drugs and it would also be contraindicated in patients who have anuria which would be the inability of

The kidneys to produce urine in terms of precautions this medication is not recommended to be used with the medication lithium should be noted that electrolyte imbalances such as hyponatremia hypokalemia as well as hypomagnesemia have all been reported with the use of this medication and the risk of experiencing these electrolyte imbalances would increase if the

Patient was experiencing vomiting sometimes severe dose related hyponatremia or low sodium has been reported especially in elderly females so in this population we would want to start off and maintain the lowest possible effective dose hyperuricemia and gout have been associated with the use of in davos the monitoring of this would be recommended manifestations

Of diabetes may occur with the use of this medication and insulin requirements in diabetic patients may be altered in patients with impaired liver function or progressive hepatic disease hepatic coma may occur with fluid or electrolyte disturbances stomach lupus erythematosus may be exacerbated or aggravated and lastly progressive renal impairment may also occur

With the use of this medication there may be a consideration to withhold the dose or discontinue the medication altogether now when somebody is cleared of the contraindications and made aware of the precautions and warnings and they start to use ind a pomide more often than not they can expect to receive their dose in oral tablet form using this medication to treat

Hypertension initially the dose would start off as one point two five milligrams taken once daily in the morning the dose may then be increased or titrated to two point five milligrams again taken once daily in the morning after four weeks of therapy in terms of the maintenance dose if two point five milligrams is not getting the patient to where they need to

Be the dose may be increased after four weeks to five milligrams however some physicians may choose to add another antihypertensive agent rather than increasing the dose due to an increased risk of hypokalemia or low potassium to treat edema associated with congestive heart failure initially the dose would start off as two point five milligrams taken once daily

And then after one week of therapy the dose may be increased to five milligrams once daily now as with all medications there are some side effects or adverse reactions that patients may experience while using adapt might or lows all so i’ll go over some of those here now hypokalemia or low potassium comes in at a rate of three to seven percent some patients may

Experience muscle cramps while using this medication dizziness comes in at five percent or greater and headache comes in at about five percent as well some patients may experience lethargy or numbness and some may experience fatigue or malaise of some more serious side effects would be dermatological reactions such as steven johnson syndrome or toxic epidermal

Necrolysis agranulocytosis and aplastic anemia may occur finally hepatitis as well as an affair access are also a risk of using and optimize so we’re going to talk about today within dap amide or lowe’s all as always a very thankful you took the time to come by and watch on my videos if you found the information valuable and you’d like to help grow this channel

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Transcribed from video