February 8, 2023


Friends, viewers, this time we will discuss about two drugs that are also part of antihypertensive drugs and also drugs used to treat chest pain or what is called angina. now, the drugs in question are nifedipine and amlodipine . is a class of drugs that block the entry of calcium ions or also known as calcium antagonists. now, let’s look at one by one. now, let’s see. what

Are the similarities, the similarities that were mentioned earlier, both of them are antihypertensive drugs and also drugs that treat pain so they are antihypertensive drugs. drugs that lower blood pressure in high blood pressure or hypertension conditions, then antianginal drugs or angina pectoris, so these are used to treat chest pain due to coronary heart disease, so

Both drugs are calcium channel blockers or calcium antagonists or calcium antagonists. this bat works by relaxing the muscles of the blood vessels , so by relaxing the muscles of the blood vessels, the blood vessels will dilate, the blood can flow more smoothly and of course blood pressure will also drop. in addition, this drug is also used to treat constriction of blood

Vessels due to raynaud’s syndrome. what is raynaud’s syndrome is a condition where the blood flow to certain parts of the body is reduced why is it reduced due to narrowing of the arteries smaller arteries that supply blood to the skin are excessive due to this condition thereby limiting the blood supply to the affected area so the symptoms are fingers, toes, ears or the

Tip of the nose, numbness and coldness, yes this condition is also often accompanied by changes in skin color, so how this drug is used in pregnant women is both category c, so studies on experimental animals have shown side effects to fetus but not yet there are controlled studies in pregnant women so it is permissible to use it if the benefits outweigh the risks to the

Fetus. then, it was also stated that amlodipine can be absorbed into breast milk. so if you are breastfeeding, do not use this drug before consulting your doctor. now for the finished dosage form , amlodipine starts to work slower than nifedipine, while itself, there is amlodipine which is available in tablets of 5 milligrams and 10 mg. this can be consumed before and after

Eating in the morning. now, several studies have shown that high blood pressure is in the state or in the morning, more or less above 09.00. in this situation, the antihypertensive drug amlodipine is given, then nifedipine. if nifedipine is in tablet form, there is a slow release and a fast release. slow release means that this will release the active ingredients slowly

So that the duration of action becomes longer. if it’s given a slow release, the working period can be longer, while the fast-release tablet is the usual way to take it three times a day. well, there’s no medicine without side effects. in general, these side effects can be the same, yes, there is dizziness, headache due to dilated blood vessels, then due to blocking the

Entry of calcium ions while calcium is needed for contraction , one of them can inhibit contractions, it can cause constipation or difficulty defecating, then there is a feeling of warmth and heat in the face, neck or chest or also called flushing can cause stomach pain or nausea as well as unusual tiredness, what is unique about amlodipine can cause swelling in the legs

And then side effects that need to be considered from these calcium antagonist drugs, especially nifedipine, which has the effect of lowering pressure quickly, this can cause the risk of a fast or irregular heart rate, . then it can cause reflex tachycardia, heart rate increases, then the following interactions can occur if it is concurrent with anti-tb drugs or tb drugs

Or rifampin, then phenytoin, carbamazepine, the anticonvulsant, yes or phenobarbital, the effectiveness of nifedipine can be reduced. this drug , rifampicin, phenytoin, carbamazepine and phenobarbital, was then combined with drugs that can lower blood pressure, such as diuretics, ace inhibitors or together with the drugs erythromycin, ritonafir, ketoconazole, fluoxetine,

Cisapride, valproic acid, or diltiazem, which in general are drugs that inhibit can also interact with food so that with grapefruit there can be an effect of increasing levels and side effects of nifedipine so you should avoid grape fruit or grape fruit products while taking nifedipine. what about amlodipine? amlodipine itself levels and effectiveness can increase if used

Together with cyclosporine erythromycin diltiazem or azole fungal drugs such as ketoconazole then levels and effectiveness can decrease if taken together with rifampin then these drugs can affect cholesterol drugs for example simvastatin so simvastatin levels can increase then can also be causes an increased risk of side effects including cardiac and vascular disorders as

Well as hyperkalemia if used with dantrolene then with tizanidine this may increase the risk of hypotension or low blood pressure

Transcribed from video
Informasi obat Nifedipine dan Amlodipine yang Perlu Diketahui|informasiobat By eRHaeS TriWidyawati