#Diabetes #BloodGlucoseRegulation #Insulin
You know i’ve forgotten about that i’m taking a class uh i’m looking at your hair and yeah you are beautiful here you are beautiful here anyway focus on your question yes what’s your question yes in the early stages how do you distinguish if a person has insulin resistance or is it insulin deficiency so that
We can treat appropriately yeah it’s very it’s yeah of course number one is the number one reasons even though clinical reasons are there right that usually type 1 diabetes in younger age and type 2 diabetes is little age but i will go to direct and hit the bullseye blood right c peptide if it is very low or
You check the level of insulin so simply in the blood check the level of insulin or check the level of c peptide which is co-secreted with insulin you know insulin granules have three types of important sense number one they are having insulin with pro insulin plus insulin granules have of course insulin plus they have
A myelin and they are having yes c peptide again i will repeat insulin granules when beta cells are functional when they release insulin they not only release insulin in equimolar amount right with insulin they release c peptide and they also release some pro insulin they also release a myelin right and so because
Insulin levels in the blood can be if c peptide levels are very low now result very carefully if c peptide level is very low it means endogenous production of insulin is very low now here i want to clear clear one concept that sometimes would happen someone is on exogenous insulin someone is taking insulin by injection
But in their patient who take the exogenous insulin their blood does not have c-peptide their blood does not have c-peptide if insulin is not being produced by pancreas so we can say that whenever insulin is present and if it is pancreatic origin it will be accompanied by the c-peptide which can be measured in the
Laboratory test in the blood but if you come across a patient who has insulin in the blood right but c peptide is very less exogenous it is not his own insulin right now we again come another way to look at it if you feel there’s a patient who has insulin level more than normal now listen very carefully manuel
Manuel james yes if if you come across a patient normal and that person is having diabetes and all clinical features of diabetes and in the blood he has hyperglycemia and hemoglobin a1c is high right for on different parameter if person is diagnosed and diabetic diabetic but if insulin is normal that along with the
C peptide in equimolar right then it means he’s producing insulin very well hyperglycemia why he is having uh why he’s having a1c the answer is that this hyperglycemia is and glucose which is present in the blood number two when you have low now again it does not work on the cells cells perception
Right and other counter regulatory hormones will be produced and they will activate lot of gluco glucose right so again i will repeat in short if you say i want in one sentence answer answer is that that if someone has diabetes and you want to be sure that diabetes is due to deficiency that’s it thank you very much for your question
Transcribed from video
Insulin Deficiency vs Insulin Resistance & C-peptide By Dr. Najeeb LecturesliveBroadcastDetails{isLiveNowfalsestartTimestamp2021-12-27T144510+0000endTimestamp2021-12-27T145242+0000}
