January 27, 2023

Lisinopril: Patient Safety Advice

Lisinopril patient safety advised pregnancy pregnant women and females with reproductive potential are advised not to take lisinopril lisinopril can cause fetal harm when administered to a pregnant woman it may cause reduction in fetal renal function and increases fetal and neonatal morbidity and death patients are advised to discontinue lisinopril as soon as

Pregnancy is detected angioedema angioedema has been observed in 0.1 percent of the patients during treatment with lisinopril lisinopril should be discontinued immediately if any signs and symptoms of angioedema are observed swelling a face extremities eyes lips tongue difficulty in swallowing or breathing abdominal pain patients are advised to consult physician

Immediately and take suitable treatment of angioedema patients taking concomitant emptor inhibitor such as tim sirolimus cyril imus everolimus may be at increased risk for angioedema patients with a history of angioedema unrelated to lisinopril therapy may be at increased risk of angioedema while receiving lisinopril lisinopril has been associated with a higher

Rate of angioedema in black than in non black patients lactation women are advised not to breastfeed during treatment with lisinopril hypotension low blood pressure excessive hypotension is rare in patients taking lisinopril alone patients are informed to report lightheadedness feeling of faintness or dizziness during the first few days of therapy if temporary

Loss of consciousness occurs patient is advised to discontinue the drug after consulting with physician excessive perspiration dehydration vomiting or diarrhea may lead to an excessive fall and blood pressure because of reduction influence are at higher risk of excessive hypotension heart failure with systolic blood pressure below 100 millimeters of mercury

Ischemic heart disease cerebrovascular disease low sodium level and blood high dose of diuretic renal dialysis a or text enosis narrowing of the aortic valve opening hypertrophic cardiomyopathy heart muscle becomes abnormally thick severe volume and/or salt to in patients with above conditions lisinopril should be started under very close medical supervision

A temporary hypotension is not a contraindication to further doses of lisinopril which usually can be given without difficulty once the blood pressure has stabilized if symptomatic hypotension develops a dose reduction or discontinuation of lisinopril or concomitant diuretic may be necessary hyperkalemia increase in serum potassium level lisinopril can cause

Hyperkalemia in about two percent of the patients patients are advised not to use salt substitutes containing potassium without consulting their physician serum potassium level should be monitored periodically in patients receiving lisinopril patients with following conditions are at high risk of hyperkalemia renal insufficiency diabetes mellitus concomitant use of

Potassium sparing diuretics potassium supplements or potassium containing salt substitutes hypoglycemia low blood sugar level diabetic patients treated with oral anti-diabetic agents or insulin are informed to monitor for hypoglycemia closely especially during the first month of combined use with lisinopril leukopenia neutropenia low leukocyte and neutrophil counts

Patients are informed to report immediately any signs of infection such as sore throat or fever as it may be associated with leukopenia or neutropenia patients with connective tissue disorder and renal disease are advised for periodic monitoring of white blood cells anaphylactic reactions during dialysis in rare patients receiving lisinopril sudden and potentially

Life-threatening anaphylactic reactions have occurred who are dialyzed with high-flux membranes in such a situation dialysis must be stopped immediately an aggressive therapy for anaphylactic reactions must be initiated different type of dialysis membrane or a different class of antihypertensive agents should be used in such patients impaired renal function monitor

Renal function periodically in patients under the treatment with lisinopril changes in renal function in a susceptible patient may be caused by lisinopril if renal dysfunction develops during treatment with lisinopril serum creatinine concentration exceeding 3 milligrams per deciliter or a doubling from the pretreatment value then the physician should consider

Withdrawal of lisinopril following patients are at high risk for developing acute renal failure with lisinopril renal artery stenosis narrowing of one of the renal arteries chronic kidney disease severe congestive heart failure post myocardial infarction volume depletion evaluation of patients with hypertension heart failure or myocardial infarction should always

Include assessment of renal function hepatic failure patients receiving lisinopril who developed jaundice or marked elevations of hepatic enzymes should discontinue lisinopril and receive appropriate medical treatment cough persistent non-productive cough has been reported with all ace inhibitors including lisinopril it almost resolves after discontinuation of

Therapy contraindications lisinopril is contraindicated in the following patients hypersensitive to lisinopril history of angioedema related to previous treatment with any ace inhibitor for example captopril ramipril thanks for watching subscribe for more videos

Transcribed from video
LISINOPRIL | How to avoid serious side effects | Patient safety advice on LISINOPRIL | Precaution By Professor Tushar