Hello everyone my generic name is furicimide and trysamide i have brand names such as lasiks and demodex my chemical names for furosemide and tyrsimide are i am classified as loop diuretics my pregnancy category as a ferocious man is category c animal production studies have shown adverse effects to the fetus and there are no adequate or well controlled studies
In human but potential benefits may warrant use of the drug in pregnant women despite having potential risks as a torsionmine my pregnancy category is category b animal production studies have failed to demonstrate a risk to the fetus and there are no adequate or well controlled studies in pregnant women in my mechanism of action i am designated to block the
Sodium potassium chloride co-transporters that are expressed along the proximal and the distal tubules in the nephron preventing the transport of sodium ions from the luminal side to the basolateral side for reabsorption resulting to increase water excretion and decrease tonicity of uric acid in the interstitial and i am binded to a chloride ion binding site of
The transport molecule to reduce the oxygen demand in the medullarific ascending loop of henle by inhibiting the sodium potassium chloride bomb on the aluminal cell membrane surface i am also known to have an effect in the iranian angiotensin aldosterone system by inhibiting its flow after the activation of angiotensin tooth and then this will produce a secondary
Effect marked by the expression of aldosterone synthase reduction and aldosterone binding reduction i am absorbed in the gi tract about 60 of those after oral administration however food may delay my response but don’t worry it doesn’t affect or alter diuretic response wait for about 30 to 60 minutes and diuresis will begin my volume of distribution is 12 to 15
Liters and it crosses the placenta barriers i am metabolized in your liver and excreted in your urine i am indicated for treating edema associated with congestive heart failure liver cirrhosis and renal disease including the nephrotic syndrome and for treating hypertension alone or with other anti-hypertensive drugs and also when rapid and extensive diuresis is
Needed i am contraindicated to patients who have anoreea or a condition which your kidney do not produce urine also to those people who have history of hypersensitivity to me those who have hepatic coma and is in a severe state of electrolyte depletion i also have side effects which are in the musculoskeletal system i can cause model spasms weakness arthialga
And myalga in your integumentary system i can cause dermatitis purpura russia’s urticaria itching and photosensitivity in your endocrine system eye can cause hormonal changes in your digestive system constipation diarrhea abdominal pain and discomfort is my effect in your nervous system i may cause dizziness fever headache and restlessness in your cardiovascular
System i may cause chest pain i have great effect in your urinary system given that i am a loop diuretic i cause fluid and electrolyte imbalance and extreme urination before administering me to the patient he must first assess if the patient have allergies to sulfonamides then assess the cardiopulmonary status to evaluate the fluid movement in state of hydration
Next ask the patient if they are taking digoxin for anorexia nausea vomiting muscle cramps paresthesia and confusion because it might increase the risk of hospitalization due to digoxin intoxication and lastly perform a thorough physical assessment to obtain baseline data before drug therapy to determine my effectiveness when giving me to the patient administer
Me orally in the morning to prevent frequent urination during sleep schedule monitor patient response upon taking me by taking their blood pressure serum electrolytes and state of hydration to evaluate my effectiveness and then assess skin condition to determine fluid volume deficit or attention and lastly you may provide comfort measures to all patients tolerate
My effect after administering me to the patient explain frequency of initial monitoring and how reviews will be followed up and arranged inquire difficulties going to the toilet in time and disruption to sleep and daytime activities since diuretics make people pass urene more frequently and lastly explain indications for my use never forget the things you have
To know about me in order for you to be safe and will keep you from any complications and serious side effects that i can give you also have to consider what other drugs i get along well so you don’t have to worry about what bad may happen always remember you have a lot to know so you are good to go
Transcribed from video
Loop Diuretics: Furosemide and Torsemide By Batch Kunzite
