June 4, 2023

Hydrochlorothiazide is a diuretic (water pill). Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker). Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.

Howdy michael davies here with the pharmaceutical company we will talk a little bit about the use and dosage of the drug and some of the side effects this medication losartan is a prescription medicine used to treat the symptoms of high blood pressure hypertension lower the risk of stroke in certain people with heart disease and diabetic nerve pain neuropathy

Losartan khosar may be used alone or with other medications cozar belongs to a class of drugs called angiotensin ii receptor antagonist it is not known if cozar is safe and effective in children younger than six years of age the most common side effects of cozar include dizziness back pain and cold symptoms stuffy nose sneezing sore throat tell the doctor if

You have any side effect that bothers you or that does not go away these are not all the possible side effects of cozar for more information ask your doctor or pharmacist cozar is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older to lower blood pressure lowering blood pressure lowers the risk of fatal and

Non-fatal cardiovascular events primarily strokes and myocardial infarction these benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan control of high blood pressure should be part of comprehensive cardiovascular risk management including as appropriate lipid control diabetes

Management antithrombotic therapy smoking cessation exercise and limited sodium intake many patients will require more than one drug to achieve blood pressure goals for specific advice on goals and management see published guidelines such as those of the national high blood pressure education program’s joint national committee on prevention detection evaluation

And treatment of high blood pressure numerous antihypertensive drugs from a variety of pharmacologic classes and with different mechanisms of action have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality and it can be concluded that it is blood pressure reduction and not some other pharmacologic property of the drugs

That is largely responsible for those benefits the largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly elevated systolic or diastolic pressure causes increased cardiovascular risk and the absolute risk increase per

Mmhg is greater at higher blood pressures so that even modest reductions of severe hypertension can provide substantial benefit relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk so the absolute benefit is greater in patients who are at higher risk independent of their hypertension and such patients

Would be expected to benefit from more aggressive treatment to a lower blood pressure goal some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients and many antihypertensive drugs have additional approved indications and effects for example on angina heart failure or diabetic kidney disease these considerations may guide

Selection of therapy cozar may be administered with other antihypertensive agents cozar is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy but there is evidence that this benefit does not apply to black patients cozar is indicated for the treatment of diabetic necropathy with an elevated serum creatinine

And protoneuria in patients with type 2 diabetes and a history of hypertension in this population cosa reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end-stage renal disease need for dialysis or renal transplantation dosage and administration hypertension adult hypertension the usual starting

Dose of cozar is 50 milligrams once daily the dosage can be increased to a maximum dose of 100 milligrams once daily as needed to control blood pressure a starting dose of 25 milligrams is recommended for patients with possible intravascular depletion for example on diuretic therapy pediatric hypertension the usual recommended starting dose is 0.7 milligrams

Per kg once daily up to 50 milligrams total administered as a tablet or a suspension dosage should be adjusted according to blood pressure response doses above 1.4 milligrams per kg or in excess of 100 milligrams daily have not been studied in pediatric patients hypertensive patients with left ventricular hypertrophy the usual starting dose is 50 milligrams

Of khosar once daily hydrochlorothiazide 12 milligrams daily should be added and or the dose of coza should be increased to 100 milligrams once daily followed by an increase in hydrochlorothiazide to 25 milligrams once daily based on blood pressure response nephropathy in type 2 diabetic patients the usual starting dose is 50 milligrams once daily the dose

Should be increased to 100 milligrams once daily based on blood pressure response dosage modifications in patients with hepatic impairment in patients with mild to moderate hepatic impairment the recommended starting dose of cozar is milligrams once daily kozar has not been studied in patients with severe hepatic impairment dosage forms and strengths cos are

25 milligrams are white oval film-coded tablets with code 951 on one side cos are 50 milligrams are white oval film-coded tablets with code 952 on one side and scored on the other cos are 100 milligrams are white teardrop-shaped film-coded tablets with code 960 on one side side effects clinical trials experience because clinical trials are conducted under widely

Varying conditions adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice cozar has been evaluated for safety in more than 3 300 adult patients treated for essential hypertension and 40 58 patients subjects overall over 1200

Patients were treated for over six months and more than 800 for over one year the following less common adverse reactions have been reported blood and lymphatic system disorders anemia psychiatric disorders depression nervous system disorders somnolence headache sleep disorders paresthesia migraine ear and labyrinth disorders vertigo tinnitus cardiac disorders

Palpitations syncope atrial fibrillation cva respiratory thoracic and mediastinal disorders dyspnea gastrointestinal disorders abdominal pain constipation nausea vomiting skin and subcutaneous tissue disorders urticaria pruritus rash photosensitivity use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces

Fetal renal function and increases fetal and neonatal morbidity and death resulting oligohydramneals can be associated with fetal lung hypoplasia and skeletal deformations potential neonatal adverse effects include skull hypoplasia onuria hypotension renal failure and death when pregnancy is detected discontinue losartan as soon as possible that’s all for today

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Transcribed from video
LOSARTAN. Uses, Dosage, Side Effects, Warnings, Interactions, Pictures By MEDICATIONS