February 1, 2023

PCRI’s Executive Director, Mark Scholz, MD, discusses the off-label use of Metformin as a treatment for prostate cancer. He describes the limitations of studies conducted up to this point, explains the logic of Metformin’s anti-cancer potential, and describes situations in which it is wise to consider using Metformin as part of a treatment plan.

Hi i’m dr. mark scholes at the peace ride we get questions about supplements and one of the most common ones is related to metformin metformin is a prescription medicine now generics been out for decades that is used by diabetics to lower blood sugar levels it’s very popular that’s very relatively safe diabetic medicine because with many diabetic medicines you’ll

See it some is a marked decline in blood sugar levels metformin doesn’t do that as commonly and people that don’t have serious diabetes can start out on metformin there been a number of retrospective trials because metformin is used so commonly you can look at people that have both diabetes and prostate cancer simultaneously there are a variety of other options for

Diabetes besides metformin so researchers have looked at men with prostate cancer and diabetes who have either received metformin or some other type of treatment for their diabetes and that they’ve compared survival rates over time in these studies the men that were treated with metformin lived longer in relation to their prostate cancer than the men that were

Treated with other types of diabetic medications one answers why did they even look at metformin why they even studied the question well there’s some logical reasons to consider given that metformin is known to lower insulin levels insulin functions kind of like growth hormone and can stimulate cancer growth so taking metformin to lower insulin logically might

Slow the progression of prostate cancer so when this was looked at retrospectively enlarged data based type trials the men getting metformin did indeed do better the problem with these trials is we don’t have one that is testing that foreman as it isolated factor that’s what a prospective trial is so even though several retrospective trials show an advantage for

Metformin over other medic medications we don’t really have a conclusive trial showing that everyone with prostate cancer should take mint foreman but considering that metformin is a fairly mild agent you can get it from your family doctor and he can monitor you it’s inexpensive and certainly men with higher risk prostate cancer in the ezzor or indigo categories or

The royal categories need every advantage they can get metformin might be a logical thing to consider in that particular scenario and the downside seems to be fairly limited so while the studies that have been published have been done exclusively in men that have diabetes it seems logical to some people although we don’t have any medical proof that metformin might

Even be helpful in men that don’t have diabetes in my own practice i tend to think of using meth foreman in my prostate cancer patients who have more serious types of prostate cancer and perhaps those that are overweight it one of the side benefits of metformin is that we will see some weight loss and some of the individuals that take this medicine so metformin

For prostate cancer and men that don’t have diabetes has so far not been proven in a prospective trial to be beneficial but there are logical reasons to believe that metformin might be beneficial even in men without diabetes and since it’s a mild agent some doctors consider using it in the say

Transcribed from video
Metformin & Prostate Cancer By Prostate Cancer Research Institute