June 1, 2023

Berberine is quite well tolerated and probably better than metformin and works equally well if not better to lower the hemoglobin A1c in patients with prediabetes or early diabetes and also has the bonus of lowering cholesterol and has some anti-inflammatory and immune supporting properties.

How old’s been studied by thousands of labs but the one that’s most interesting i think right now is to see if a drug that activates ampk extends human lifespan slows down ajmpk it’s called amp-activated kinase we want to activate ampk so how do you do that uh you actually you eat less you fast and that’ll turn on ampk it’ll do a few things it’ll make your body

More sensitive to your insulin suck the sugar out of your bloodstream which can be toxic if it stays high but it also ramps up the energy producing centers of the body these membrane-filled bags which are actually ancient bacteria living in our bodies called mitochondria yeah metformin’s really interesting because it’s super safe it’s one of the safest drugs ever

Known it’s on the world health organization’s list of essential medicines for humanity in much of the world it’s it’s cost pennies and you can get it in those countries they just want you to have it like aspirin in the u.s and a lot of english-speaking countries in europe you need a prescription for this drug and it’s the frontline therapy for type 2 diabetes or

High blood sugar so why do we think that metformin actually works well first as we my lab in collaboration with rafael de cabo down at the national institute on aging showed in a mouse study that if you give them metformin those mice are healthier and live longer again doesn’t prove that it works in humans but you can take tens of thousands and people have taken

Tens of thousands of people who are on metformin for type 2 diabetes and looked at their overall health and their lifespan and this fact that i’ll tell you blows my mind type 2 diabetic diabetics that go on metformin on average live longer than people that don’t have type 2 diabetes and they’re protected against diseases so if you’re susceptible to cancer or

Heart disease frailty those on metformin reduce their risk of those diseases whereas those that don’t take metformin it increases over time based molecules from the bird plant i believe it’s from india by red collection in any case you can buy it it should be bright yellow and it’s been shown in my lab and others in animals to greatly protect against type 2

Diabetes and work similar similarly to resveratrol and it’s been shown in many clinical trials now if you take a gram um and in many cases two grams which is a lot uh it will help treat type 2 diabetes now we don’t know if it will extend lifespan but it does seem to do the same kind of things that meant foreman does and metformin seems to have all the hallmarks

Of a lifespan extending drug so i think berberine is a good option i used to take berberine before i had metformin and i was taking a gram every morning but again it’s also insoluble so think about the yogurt and the oil options as well it can be additive meaning that it can be beneficial to take both and again you do that under your doctor’s supervision of

Course because it’s actually quite a strong combination but it can help if metformin is insufficient or berberine on its own is not sufficient to bring down your blood sugar levels but improve your overall metabolism then the combination can actually work even better you

Transcribed from video
Metformin vs Berberine For Longevity. Metformin and Berberine Together | David Sinclair Sweet Fruit By Sweet FruitliveBroadcastDetails{isLiveNowfalsestartTimestamp2022-03-25T160012+0000endTimestamp2022-03-25T160608+0000}