Leukotriene inhibitors are the first new class of medications for the treatment of persistent asthma that have been approved by the U.S. Food and Drug Administration in more than two decades. They also have been approved for the treatment of allergic rhinitis. Prescriptions of leukotriene inhibitors have outpaced the evidence supporting their use, perhaps because of perceived ease of use compared with other asthma medications. In the treatment of persistent asthma, randomized controlled trials have shown leukotriene inhibitors to be more effective than placebo but less effective than inhaled corticosteroids. The use of leukotriene inhibitors has not consistently shown an inhaled-steroid–sparing effect, a reduction in need for systemic steroid treatment, or a cost savings. For exercise-induced asthma, leukotriene inhibitors are as effective as long-acting beta2-agonist bronchodilators and are superior to placebo; they have not been compared with short-acting bronchodilators. Leukotriene inhibitors are as effective as antihistamines but are less effective than intranasal steroids for the treatment of allergic rhinitis. The use of leukotriene inhibitors in treating atopic dermatitis, aspirin-intolerant asthma, and chronic idiopathic urticaria appears promising but has not been studied thoroughly. Leukotriene inhibitors have minimal side effects and are well tolerated in most populations.
Assalamualaikum everyone this is rp sphere and welcome to the platform of pharma video once again with a new video of drug that is montillokas and this is the drug 12 of the truck series so let’s begin the video montillo cost belong to the drug category that is like rhine antagonist so what is the liquid trine and how its antagonize the liquid rhine this is
Basically the complex picture so let’s understand from this picture phospholipids phospholipids converted into the archetonic acid and it undergoes to the two pathways that is a cox and the locks pathway by the cox pathway it formed the pgs and thromboxane pg is basically the prostaglandins and by the lux pathway that is a lip oxygenase pathway it forms liquid
Lines and this is the lock cream locked trail is a brand name of montero cast luck will inhibit this step and it inhibits its binding with the liquid trine receptor so basically it antagonize the like activity mind with the systematic ecotrine receptor that inhibit the asthma symptoms that are causes the bronchoconstriction increase the mucous secretion increase
The vascular permeability and causes the edema so ultimately there is no asthmatic symptoms because loctrill that is a montelocast montero class inhibit the cystenyl ecotrine receptor and in the previous picture as you can see it inhibits the cysteine liquid ion receptor and here you can see the sestana liquid rhine that is a ltc4 d4 and e4 so this is the basic
Picture of cysteine cotron receptor antagonism now its pharmacokinetic properties that is absorption distribution metabolism and elimination pattern its bio availability is 64 percent and its peak plasma time is in the tablet form with the three to four hours it is available in the chewable tablets and it’s a granules form in the granular form its peak plasma time
Is one to three hours and is a chewable tablet two to two point five hours its distribution it is highly protein bounded that is 99 percent and its vdd that is a volume of distribution it’s 8 to 11 liter this is basically the pharmacokinetics parameter as you learned in the pharmacokinetics now metabolism it is metabolized by the 3a4 enzyme most of the drugs are
Metabolized by this enzyme so it is highly indirected drug and cytochrome 2 c9 now its elimination pattern half-life is 2.7 to 5.5 rn clearance is 45 ml per minute excretion in the pieces which is the major route of excretion that is 86 percent and in the urine 0.2 percent so in the pregnancy no evidence of the risks and human anal in lactation caution must be
Advised but it is quite not safe but indicated in the pregnancy now it’s indication add-on therapy to the mild to moderate asthma and adequately controlled by inhaled cardiac asteroids and short acting beta to agonist exercise induced bronchoconstriction now its dosage in others 10 mg daily at the bad time it is taken as hs that is a bad time as a pharmacist you
Should know what is the meaning of hs i just mean bedtime with or without food and the children and the p dosage is prophylaxis in asthma six one two six air four mg once daily that is means od in the evening six to twelve uh years five family od in the evening 15 to 18 years 10 mg1 steely that means od children symptomatic relief of seasonal allergy rhinitis
In the children with the asthma of 15 to 18 years 10 mg once daily in the evening precautions do not substitute for the inhale oral corticosteroid therapy that mean you cannot switch to the oral cardiac steroid therapy do not use for the relief of acute symptoms because it can worsen the acute symptoms of asthma especially phenylketonuria virtual able tablet
It can precipitate out the phenylketonuria because it contain the aspartate and this is available in the artificial sweetener now what is this this is a sharkstar sunroom and in this condition you can use this truck with more and more precautions and this is basically the inflammation of the blood vessels so there is no blood flow even to the links and it can
See in the patient of asthma then this syndrome can precipitate out the asthma montelukas also induce this syndrome that is a shark stress syndrome now interaction its interactions are phenobarbital with phanytwine and the riflempisin because these are the candidate for the enzymes that are cytochrometeria for which are the enzyme required for the metabolism
Of montillo caste now its adverse effect is major adverse effect are abdominal pain headache and thrush now what is a tip point in pakistan montilloka is available with the brand name of mitika and that’s all from this truck and from this video until
Transcribed from video
Montelukast | Treatment of Asthma | Antileukotriene (LTRA) By PharmaPhilia Academy
