March 28, 2023


Hello my name is jennifer burleigh and i’m a pharmd candidate for the class of 2022 and today i will be going over receivastatin also known as crestor i will begin with a brief overview of versuvostatin resuvastatin also goes by the brand name crestor it belongs to the statin drug class family it’s used to lower bad cholesterol triglycerides and fats and raise

The good cholesterol it’s also used to lower the chance of a heart attack stroke and slow heart disease progression and it works by reducing the amount of cholesterol produced from the liver now i will go over some patient counseling points for resufa statin you should take this medication at the same time each day swallow this medication whole and take with

Water and with or without food keep me taking this medication as you’ve been told by your doctor even if you begin to feel well do not take resuve statin if you are allergic to any part of this medication tell your doctor if you have liver disease or raised liver enzymes do not take receive a statin if you’re pregnant or breastfeeding avoid or limit your alcohol

Consumption to less than three drinks per day because drinking too much alcohol while taking this medication may increase your chance of lizard disease take antacids that have aluminum or magnesium in them at least two hours after taking receptostatin and if you miss a dose take it as soon as you remember but do not take two doses of versus statin within 12 hours

Of each other some common adverse effects of versus statin include headache abdominal pain muscle pain nausea weakness and dizziness some more serious adverse effects of versus statin include fever unexplained or unusual muscle pain weakness unexplained or unusual weakness decreased appetite abdominal pain dark colored urine and yellowing of the skin or eyes if

You experience any of these serious adverse effects seek immediate medical attention next i will go over fda approved indications and dosing for resuvastatin rasuva statin is approved by the fda as an indication heterozygous hypercholesterolemia and patient would take 20 or 40 milligram oral tablet once daily for homozygous hypercholesterolemia the patient would

Take 40 milligram oral tablet once daily for primary prevention of ascvd or atherosclerotic cardiovascular disease the patient would take 20 to 40 milligram oral tablet once daily for secondary prevention of ascvd the patient would take 20 to 40 milligram oral tablet once daily and then for patients with high risk ascbd they may require additional therapies to

Achieve their ldlc goal and then referral to a lipid specialist should be considered if treatment goals are not met now i will go over formulations and dosing adjustments for receivastatin formulations so the brand name crestdoor is an oral tablet and it’s available in five milligram 10 milligram 20 milligram and 40 milligram the generic resuva statin is also an

Oral tablet and it is available in 5 milligram 10 milligram 20 milligram and 40 milligram and the esolar sprinkle oral capsule is available in five milligram 10 milligram 20 milligram and 40 milligram and then for renal dose adjustments for mild to moderate renal impairment patients there’s no dose adjustment required for patients with severe renal impairment

You would start them at a five milligram orally once daily tablet and then for hepatic dose adjustments the use is contraindicated in patients with active liver disease and then for patients with chronic liver disease you would start them at five milligram orally once daily i will now go over the mechanism of action of versus statin versus statin is an hmg coa

Reductase inhibitor that inhibits the conversion of hmg coa to malevolent and cholesterol synthesis this inhibition results in an increase of ldl or low density lipoprotein receptors on hepatocyte membranes and stimulation of ldl breakdown hmg coa reductase inhibitors also decrease levels of high sensitivity c reactive protein or crp crp is a protein found in

The blood that is sent into the bloodstream in response to inflammation it lets you know whether your body has an infection or is injured therefore high levels of crp indicate a serious infection resuva statin also possesses other properties including inhibition of platelet aggregation anticoagulant effects reduced inflammation at the site of a coronary plaque

And improved endothelial function i will now go over the warnings precautions and conjure indications of versus statin warnings and precautions include patients with diabetes they may experience a small increase in their a1c and fasting blood glucose has also been reported patients with hepatotoxicity a liver enzyme test should be obtained at baseline and as

Clinically indicated and then patients with myopathy so patients should report any unexplained muscle pain tenderness or weakness because this may be a sign of a more serious condition called rhabdomyolysis and then patients with the history of liver disease and or a history of chronic alcohol use in patients with also myasthenia gravis because it can worsen

This condition and then patients with renal impairment specifically in patients with a creatinine clearance of less than 30 because they may require a dose adjustment and then contraindications for receivastatin include patients with hypersensitivity to any part of the medication pregnancy and breastfeeding active liver disease patients and then patients who

Experience and explain persistent elevations of serum transaminases monitoring parameters for resuva statin include monitoring the for the lipid levels and the lipid levels would include like ldl which is your low density lipoprotein your hdl or your good cholesterol your triglycerides and your total cholesterol and these should be obtained within four weeks of

Dose initiation to establish a baseline or again if there’s like a dosage change in the receivastatin then signs and symptoms of myopathy should also be monitored and those include like any muscle pain or weakness and then hepatotoxicity monitoring should also be completed during using receivastatin such as lft should be performed at baseline and then 12 weeks

After initiation a therapy and then again every six months after that these are my references thank you for listening to my presentation

Transcribed from video
Rosuvastatin – Crestor By Riverside Rx Services