December 8, 2022

Sertraline is an antidepressant in the SSRI class. It’s used for depression, anxiety, panic disorder, OCD, and a number of other conditions.

Along with being used for depression, it is as always, there will be more information the primary positive effects include depression reduction, mood improvement, and anxiety reduction. dry mouth, drowsiness, dizziness, tremor, and fatigue. ptsd, premature ejaculation, and premenstrual dysphoric disorder. it has a similar efficacy to other ssris, there are some trends

In favor of its efficacy it’s specifically used as a first-line treatment in cases of depression where someone has cardiovascular although it does work in the long-term for even if treatment is continued in someone for minors, the primary indication is in ocd, it might be effective in other disorders like depression and anxiety. some benefit is often noticed after the

First the primary negatives in medical settings headache, increased sweating, dry mouth, agitation, and insomnia. patients may experience decreased libido, sexual dysfunction appears to be less significant with sertraline compared to paroxetine, citalopram, for other negatives, it may cause less constipation, sertraline is an isomer of a tametraline derivative. some minor

Dopamine reuptake inhibition does how ssris provide their beneficial effects still isn’t understood. there’s an immediate impact on serotonin activity, i’ll briefly discuss a few possibilities, an overarching view is that adaptations in the brain are responsible. bdnf could also be playing a role as it’s bdnf seems to increase with sertraline and along with raising bdnf,

There are other possible as such, the drug might be providing its benefit there’s a high serotonin hypothesis that’s energetically expensive state associated with higher serotonin activity. actually provide benefits by altering serotonergic another way of looking at the effects involves there’s evidence that they could move the this kind of impact on processing enables in

1977, kenneth koe, a chemist in the pfizer features of potent and relatively selective uptake inhibitors. those derivatives were tested and sertraline they showed sertraline was an effective serotonin uptake blocker in rats. studies in humans found it was well-tolerated the fda approved sertraline under the name between the 1990s and 2000s, the drug was this meant patients

Were also often unaware knowledge about the withdrawal effects has around 2005, the drug was generating revenue of $2 to $3 billion annually. the drug is usually started at 25 to 50 mg per day. sertraline is unscheduled in the us, though it’s a prescription-only substance. sertraline has historically been viewed as largely safe in orverdose. some of the symptoms include

Drowsiness, tachycardia, even up to a few thousand milligrams has been largely non-problematic. in medical settings, most of the severe adverse effects are rare. sertraline may also increase panic attacks when there are negative effects, they’re more there are some potential liver health concerns it normally has no or very minimal effect on the liver, but a few reports

Exist of hepatotoxicity. serotonin syndrome is one of the concerns with sertraline. although it could potentially occur with sertraline it’s most often a concern when another serotonergic drug is used. serotonin syndrome can be deadly, but most it doesn’t occur for everyone, but a significant usually the symptoms appear within a few days they then resolve between 1 day

And a few weeks after the onset. some of the effects include flu-like symptoms, another issue is electric shock sensations that very in intensity. prolonged symptoms lasting more than 6 weeks those include disturbed mood, depression, these issues can be distinct from the patient’s original condition. people report prolonged issues lasting months or years. a good strategy

To potentially reduce the severity of symptoms. most of the data suggests there’s a very low a sudden onset of aggression and suicidal ideation is possible. monitoring a patient is especially important during the first 1 to 2 months. the risk may also vary to some extent between some of the risky combinations include maois, dextromethorphan, and tramadol.

Transcribed from video
Sertraline (Zoloft): What You Need To Know By The Drug Classroom