In this gout series today, I’ll tell you how does allopurinol works, and what are the side effects you should be looking out for if you’re taking it for your gout!
Says! in this gout series today i’ll tell you how does allopurinol works and what are the side effects you should be looking out for if out on my previous video where i talk about home remedies for the treatment of gout, you can click on the link above. now, let’s get on to it. briefly see how does allopurinol
Works. if you watched my previous videos, you should know by now that gout is caused by high levels of uric acid in your body. allopurinol works by inhibiting an enzyme known as xanthine oxidase which is responsible for the conversion of purine to uric acid. hence it is also known as a urate-lowering
Drug. allopurinol is mainly used by doctors in three conditions. the first and most obvious is for the treatment of gout second, it is used to prevent calcium and uric acid stone formation in stone one must also drink plenty of water and lastly, allopurinol is also commonly used in blood cancer patients to prevent tumor
Lysis syndrome. a condition where after chemotherapy a large number of tumor cells are killed and plenty of uric acids is released into the bloodstream causing complications. those who are familiar with allopurinol should know that it comes in two formulations, 100 milligrams and 300 milligrams. our patients
With a low dose of 100 milligrams and slowly titrate up by 100 milligrams every two to four weeks, depending on the uric acid levels. the aim is to reach and maintain uric acid levels of less than six milligrams per deciliter or in the case of tophaceous gouts, the ones with lumps and bumps over the body, a
Lower level of less than five milligrams per deciliter. the maximum dose one can go to is up to 800 milligrams per day. when one is taking more than 300 milligrams per day, it is recommended day rather than to take it all at once. now, what you may not know and is super important is the dosage of patients with chronic
Kidney disease is way much lower! this is a table of suggested initial doses for patients with kidney disease depending on their kidney function levels. as you can see, the poorer your kidney function is, the lesser the dose. patients with gout usually have some sort of chronic kidney disease, and any
Monitored for side effects by your treating physician. so, the question is, do you know your kidney function if you are on allopurinol? now, let’s move on to the side effects. the number acute gout attack! yes, you heard me right! i’m not pulling your leg. let me explain the usually happens when one is first started
On caused by uric acid crystals known as monosodium urate crystals in your joint. allopurinol will dissolve these crystals deposited in your joints, and when this happens it causes a paradoxical effect of gout flare. this is especially true begin with. this is why allopurinol must never and your doctor
Will usually co-prescribe anti-inflammatory drugs like nsaids or colchicine after a few weeks or months, so be patient! do not stop this drug prematurely if you don’t see any improvement within the first few weeks, give it some time to do its job! the second side effect is delayed hypersensitivity reaction.
Adverse reactions like steven johnson syndrome, toxic epidermal necrolysis, and dress aka drug reaction with eosinophilia and systemic symptoms. the risk factor to develop this hypersensitivity is the presence of a gene called hla-b*5801. it is quite common in the asian population especially korean, han chinese, or thai
Descent. so, if you are asian it is advisable to undergo this gene testing before starting on allopurinol. the risk is also higher if one has kidney impairment, to begin with. the third and last side effect is hepatotoxicity, which means toxic to your liver. it will cause your liver enzymes to be raised or
Deranged and the risk factors are african american descent or pre-existing kidney disease. so, there you have it guys, that’s all you need to know about allopurinol! don’t forget to leave a comment down below if any of you develop any side effects while on allopurinol. i’ll be grateful if you can smash the like button,
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Transcribed from video
SIDE EFFECTS of taking Allopurinol (Zyloprim) in GOUT | Allopurinol DOSAGE and mechanism of action By Doctor Says
