Stevens-Johnson syndrome is a type IV (subtype C) hypersensitivity reaction that typically involves the skin and the mucous membranes.
So today we’re going to look at steven johnson syndrome in this video we shall be discussing the causes the clinical features the diagnosis the differential diagnosis treatment and the complications associated with steven johnson syndrome what steven johnson syndrome this is a lot typical tiger lesion with less than 10% total body surface area involvement this
Syndrome is characterized by blistering of the mucosa detachment of the epidermis from the damaged layer and every domina croesus in this case there is a rapid progress of erythematous modules into development of era through dima and abdullah the most common cause is drugs and some opportunistic infection numerous studies giovanni toxoplasmosis and mycoplasma
Infections mostly in children all these three interactions are optional stick infections in immunocompromised patients early life seem of antigen presenting major histocompatibility complex locate such as the carriers of a human leukocyte and in 1502 and at a higher risk while compared to other people the most common drugs associated with stevens also syndrome as
Sulfonamides like sulfamethoxazole try metro cream and nevirapine with an antiretroviral drug nancy radio anti-inflammatory drugs anticonvulsants that are used to treat seizures and convulsions i hope you know which is a drug that’s used in the treatment of gouts lamotrigine and along lipton steven johnson syndrome is a side effect of these medications our patient
Which steven johnson syndrome will present with fevers of more than 39 degree celsius painful skin lesions biologist all muscle pains generalized body malaysia conjunctivitis so trolls and these patients will complain having pain on eating swallowing and urinating because of the involvement of the urethra 90% of these patients will present with involvement of
The mucosa solids the army cosa believes the conjurer tama and the daily italia so how do we diagnose a patient with steven johnson syndrome when conducting our physical examinations this question will present with a postive nicole sign and a frozen skin biopsy is the one that will give definitive diagnosis of steven johnson syndrome the direct immunofluorescent
Hace it will be negative in these patients what is nicole sign okay when you apply a manual pressure on this prescience skill there will be a separation of the epidermis from the underlying damage this is a positive nicole side okay the differential diagnosis that you mating when a patient presents with similar features like in steven johnson syndrome is features
Upper features a cure system with lupus erythematosus and suet syndrome what’s the treatment of steven johnson syndrome basically there is no definitive treatment for these syndrome but ally stoppage of the causative drugs which led to the development of the syndrome before the development of beulah is important you will also need two innate these patients in an
Acute care setting such as an intensive care setting or units and fleet with nutritional support alistair bird use and cyclosporine use together it intravenous immunoglobulin you these patients have a high morbidity mortality rate because of the infections electrode imbalances hypovolemia and septic shock
Transcribed from video
Stevens-Johnson Syndrome: Causes, Diagnosis, Differentials, Symptoms and Treatment By Medcrine
