February 8, 2023

“I personally love engaging and working with people that have bipolar disorder. I think it’s one of the most rewarding fields of medicine to study, and I feel incredibly privileged to study this illness” – Dr. Melvin McInnis, Research Director, Heinz C. Prechter Bipolar Research Fund.

The study of bipolar disorder is the study of humanity. man has never been dante’s inferno than in the depressive state and so studying bipolar disorder passions can get into a pathological state which is what we call mania and our goal is to understand what makes them well what causes problems but most able to engage the energy of the university of michigan the energy the

Harnessing the power of cell and developmental biologists, of computer clinicians that we have here focused on this illness to understand how the most interesting projects are done in collaboration with other labs across the cell project that we have going with dr. sue o’shea at cell and developmental healthy controls to provide us with a skin sample, a little sample of

Their time into what is called pluripotent stem cells and grow them into nerve will derived from individuals with bipolar disorder and comparing example that these cells are highly reactive they react in a much more actually respond to lithium so they’re calmed by lithium so the impact of this michigan is that we’ve developed a model by which we can study bipolar disorder

Similar to what lithium does because not other really fascinating things that we’ve been finding with bipolar disorder growing into neurons is that there is a difference in the way these cells life i hear very frequently that patients and mothers will tell me you actually that is that that is true that these cells somehow develop in a so in fact there is evidence in the lab

That cells derived from someone with someone who does not have bipolar disorder so this is really critical to as a developmental disorder it’s an illness that starts early in life and illness so one of them are interesting directions that research in medicine is about the fact that in our average handheld device there’s more computing question is how is technology going

To help us going forward in healthcare it’s number of different mobile health programs and testing many of them when individual outcomes for rapid intervention so essentially what it is as they’re talking it doesn’t take the doesn’t capture or record the incoming computer science and engineering team they’re led by emily provost who’s acoustics that associate with mood

States and potentially predict mood many years people have been telling me you know when somebody gets out i have a their voice there was something different about them i couldn’t quite thought well if a human brain can integrate this kind of knowledge can we individual is speaking that would be able to predict a state change or a these shifts and potentially identify ways

To intervene and prevent these the study of the micro biome. the microbiome that reside in our gut and so we’ve identified that individuals with bipolar studying samples from the stools of individuals with bipolar disorder and found in individuals with bipolar disorder and the patterns are reflective is compromising several things including of sleep and their just level of

Of emotional well-being so our study is improve the balance of their diet improve the balance in their microbiome patterns their energy their ability to exercise and choose a healthy diet in is studying humanity. i personally love engaging working with people that have study and i feel incredibly privileged to study this illness.

Transcribed from video
"The Study of Bipolar Disorder is the Study of Humanity" By Michigan Medicine