March 24, 2023

Insulin resistance is bad, right? For most of us, yes, it most certainly is. However, there are special instances when insulin resistance is very natural and beneficial.

I am constantly amazed by the number of people that are confused about physiological insulin resistance versus pathological insulin resistance physiological insulin resistance is when the body becomes insulin resistant on purpose and it’s serving a good purpose pathological insulin resistance the one that i study more explicitly is when the body’s becoming insulin

Resistant and it’s a disease state so it’s not it was never supposed to be insulin resistant and now that it is it’s actually causing other problems phys but what they have in common whether it’s pathological insulin resistance or physiological insulin resistance and this is where so many people get it wrong in both instances insulin is high so any time someone

Is invoking physiological insulin resistance say in the context of a low carbohydrate diet that’s not right because insulin goes down a lot the the insulin of the insulin levels of the person are exquisitely low this is not insulin resistance that might that’s something else and we’ve talked about in previous videos but it is not insulin resistance physiological

Insulin resistance is just like pathological insulin resistance in that in both states insulin levels are a lot higher now right behind me is a slide of a lecture that i’ve been preparing this is uh the the slide is actually highlighting the changes in insulin resistance and insulin over time in a woman who is pregnant so you can see here i have insulin resistance

And that’s this dark curve and then on this axis i’m saying insulin you know but kind of same same directions here and you’ll see this is in the life of the woman pre-pregnancy during pregnancy and postpartum in both instances we have this dramatic increase in both insulin resistance and in the amount of insulin in her body now further in this lecture actually i

Highlight some of the mechanism that explains it but pregnancy is one of the two known periods of physiological insulin resistance in the life of a person it’s the two ps puberty and pregnancy both of those instances periods of explosive growth tissue growth are states of insulin resistance and yes in both of them insulin is elevated during that period of insulin

Resistance now just to really put a fine point on this i wanted to show you the next slide this is from a study that looked at the average amount of insulin needs the insulin requirements of of women who are type 1 diabetic but also become pregnant and you can see over the course of the pregnancy look what happens to their insulin requirements and that’s because

The the insulin resistance during pregnancy is a state of high insulin her body needs more insulin and so the insulin actually is almost double the insulin needs have almost doubled at the peak of the pregnancy right before birth anyway so it’s just some thoughts about physiological insulin resistance to wrap it all up what pathological insulin resistance and

Physiological insulin resistance have in common is that insulin is elevated if you ever hear somebody invoking physiological insulin resistance in the context of a low carb or ketogenic diet laugh in their face and make sure they know that they’re wrong that is not true those are not states of physiological insulin resistance the two are puberty and pregnancy and

In both instances insulin is elevated if there’s no elevation and insulin then the body is not experiencing insulin resistance

Transcribed from video
The Two Types of Insulin Resistance By GetHLTH