-Laura Ashmore
Today i’ll be talking about the use of molestation to treat osteoarthritis and cats the cons of osteoarthritis is often unknown that the in stage disease is the same a decrease in protocol i can content in articular cartilage leads to chondromalacia degeneration of cartilage and death of condo sites this degeneration activates macrophages which will secrete
Interleukin 1 and tumor necrosis factor alpha this will then promote the secretion of prostaglandins which will induce inflammation and pain as well as inhibit proteoglycans synthesis which will lead to a cycle of degeneration malec secam is an oxy can in the class of non-steroidal anti-inflammatory drugs its mechanism of action is to selectively inhibit cox-2
This inhibits the production of prostaglandins from arachidonic acid at sites of information while having minimal effect on cox and the kidneys and gastrointestinal tract thus reducing the risk of adverse effects inhibiting production of prostaglandins will reduce the induction of inflammation and pain there are many decent studies showing the efficacy of long
Term treatment of osteoarthritis and cats with malak secam i will go over two of them briefly the first one is an experimental study in which eight healthy cats were each given a different dose of lexicon for four days cleaning two kits that were given to placebo then synovitis was experimentally induced into one of their stifle joints the efficacy of lexicons
Analgesic properties were assessed up objectively and subjectively here’s an illustration of one of the objective measures contact pressure as you can see from the graph the cats that were given the placebo were most reluctant to put weight on the affected limb while cats treated with moxie can we’re willing to put more pressure on the limb the strengths of this
Study was it was an experimental study so the researchers have more control which meant less possibility for confounding variables and they use objective measures the biggest weakness of the study was that there was a risk of bias because two of the authors were employees of boehringer ingelheim the manufacturer of medicham the lexicon the study was also funded
By them as is most of the available published literature on lexicon the second study is a prospective clinical trial in which there were two groups of cats with osteoarthritis one group was treated with millech scam daily and the other group was treated with glucosamine chondroitin daily owner assessed mobility scores showed that lexicon is effective in improving
Mobility and activity levels and cats with arthritis bob glucosamine had no significant effect the strengths of this study was that it was double blinded randomized placebo-controlled and there were no conflicts of interest no connection to boehringer ingelheim the weaknesses of this study was that there were low patient numbers and there was a lack of objective
Scoring it is worth mentioning that long-term use of mexican and cats in the united states is awful able use only as there have been some incidences of renal failure and death however the evidence has primarily been anecdotal since then many studies have been published showing the safety of long-term use of mexicali cats and long term use and katz is registered in
Many countries including australia new zealand the uk in europe with few adverse reactions reported however there is still a risk the best bets can do is to assess the risk and to try to minimize it by taking the appropriate measures such as using the lowest effective dose and regular monitoring thank you
Transcribed from video
The use of meloxicam to treat osteoarthritis in cats By Laura Ashmore
