December 9, 2022

Today’s topic of discussion is vitamin-D and its effects on health

Hi this is dr raj singh i practice at healer primary care and seven her medical spa in las vegas today’s topic of discussion is vitamin d and its effects on health now our understanding of vitamin d and its role on health has evolved significantly still there are multiple conflicting guidelines and recommendations in today’s video we are going to dive deep

Into vitamin d and learn everything about so let’s get started so first of all what is vitamin d it’s also called as calciferol it’s fat soluble and we get it primarily through food and through sunlight now although it is called a vitamin vitamin d in fact is more closer to a pro hormone because it has a steroid based structure and acts on multiple receptors

Throughout the body to exert its effect now although vitamin d is abundant in nature almost 50 personal world’s population is considered vitamin d deficient types of vitamin d so there are natural analogues which are vitamin d1 through d5 we’ll be focusing primarily on d2 which is called argo calciferol which is plant-based and d3 or cholecalciferol which is

Present in animal-based food now the synthetic analogues are also available however they are available by prescription only and primarily used to treat psoriasis and bone disease in kidney patients sources the richest source of vitamin d3 would be foods such as you know fatty foods card liver oil egg yolk beef mushrooms are the only plant-based source that are very

Rich in vitamin d now certain growers will actually expose mushrooms to uv light to increase the concentration of vitamin d so you can see this picture sunlight converts argosterol in mushrooms to vitamin d2 or argo calcifro now aside from food the best source of vitamin d are sunlight and of course supplementation one of the major causes of deficiency is lack

Of exposure to sunlight because you know we’re spending most of our life indoors these days and we often wear sunscreen when we are outside wearing a sunscreen with a spf of 30 or higher can reduce vitamin d synthesis in the skin by more than 95 percent if you have a darker skin of course you are going to be more likely deficient and you need more sun exposure

Approximately 20 minutes of direct sunlight about four times a week is considered adequate if you’re in a very polluted area you will need more vitamin d because pollution does block uv light now certain countries where full body clothing is born will also have increased deficiency of vitamin d now once we do absorb it it’s packed into small molecules called

Chylomicrons which are absorbed into the lymphatic system and then enter the liver by a portal vein chylomicrons are these molecules which are made of cholesterol triglycerides and phospholipids so you can see in this picture of the structure now since we need fat containing chylomicrons to transfer vitamin d to the liver any disorder that is associated with fat

Male absorption you know celiac disease crohn’s cystic fibrosis disease they all will be associated with low levels of vitamin d or vitamin d deficiency vitamin d is stored in our liver and in the fat tissue and can be used by the body on an as needed basis now theoretically vitamin d is inactive so it has to be activated first initially goes to the liver and

Then goes to the kidney before our body can use it so any patient with liver disease or kidney problems will have low levels of vitamin d now what causes deficiency so many things unbalanced diet limited exposure to sun dark skin if you’re overweight especially with a bmi more than 30 liver or kidney problems certain medications such as phenytoin weight loss

Surgery we covered the inflammatory bowel disease before strictly vegan diet you know no eggs for example what are some of the functions now traditionally we always thought vitamin d you know equals bone health but actually has many other functions if you have deficiency in vitamin d there’s increased risk of osteoporosis and osteopenia we know that also poor

Muscle strength increased fatigue cramps in our legs blood pressure goes up and immune system issues now patients with vitamin d deficiency are known to have increased risk of autoimmune diseases recent data also shows that patients who have vitamin d deficiency tend to have more severe lung disease if they catch covad-19 infection of course increases parkinson’s

Disease diabetes increase inflammation it can also lead to certain mutation which can increase risk of cancer risk because vitamin d does help in apoptosis which is natural cell death urinary incontinence and some cases of bacterial vaginosis also have been reported in patients who are deficient in vitamin d so as you can see it serves many purposes other than

Just the bone that we initially thought it does certain issues we all need to be aware of so first of all vitamin d for best results always should be combined with calcium if the calcium intake is inadequate taking vitamin d actually can cause increased loss of bone it also shows that if you take more than five thousand units of vitamin d every single day can

Cause more side effects and can lead worsening of bone disease too much vitamin d will cause calcification of blood vessels among other problems increases of kidney stones of course if you’re taking too much vitamin d so there are issues to be aware of when it comes to vitamin d what is considered optimal level so first of all we can do a simple blood test to

Monitor levels of vitamin d we always measure 25 hydroxy or 25 vitamin d because it has a longer half-life of about two weeks so ideally you want a level between 50 to 75 much higher level means more side effects now supplementing with two uh 2000 to 4 000 units per day may be needed to bring up the baseline value to optimal range once the optimal level is achieved

Then the dose needs to be reduced to about 600 to 800 units per day patients who are overweight especially bmi more than 30 will need much higher doses alternatively you can also take a tablespoon of card liver oil every single day to supplement the vitamin d level negative effects so just like you know too little is bad taking too much is also bad the liver is

Our usual storage site for vitamin d so when you take too much vitamin d the excess amount is going to be stored in liver and then the fat now once the fat becomes saturated then you will start seeing toxic effects so which will be from high calcium levels confusion lack of appetite muscle weakness long-term exposure will cause you know kidney stone bone loss and

Even pain in the bones so to summarize everything so vitamin d is very important first of all and serves many many functions maintain levels between 50 to 80 nanomoles per liter for best results take calcium along with vitamin d or at least have a good calcium diet and you know you might need higher doses initially but after that you need to decrease the dose

To minimize these side effects so that’s it for today i hope that was helpful and you learned a little bit about vitamin d if you did like the content please do not forget to like and subscribe and this is dr raj singh from las vegas take care bye

Transcribed from video
Vitamin D By HEALOR