December 8, 2022

Fluoxetine and paroxetine are two medications that are used to treat depression as well as other mood and anxiety disorders they are both part of the family of drugs known as selective serotonin reuptake inhibitors ssris both drugs have a similar action in the brain and exert similar effects there are important differences between them however that lead to differences

In how and when they are prescribed some patients with depression show differences in their responses to fluoxetine versus paroxetine this is due to individual differences in an enzyme in the brain called the politely copper iodine pgp transporter certain people have copies of this protein that cause it to be extremely active and remove paroxetine from the brain

Before it can affect an individual fluoxetine is not affected by the pgp transporter so it can treat depression in individuals with the more active version of this enzyme both fluoxetine and paroxetine prevent the neurotransmitter serotonin from breaking down in the brain this allows serotonin to exert greater effects on the brain as a result slight differences

In their actions mean that these drugs can be used to treat slightly different disorders for example fluoxetine is typically used to treat bipolar disorder and cataplexy whereas paroxetine is most often used to treat generalized anxiety disorder and erectile dysfunction both drugs are used in the treatment of major depression bipolar disorder panic disorder and

Obsessive-compulsive disorder however the length of time these drugs remain in the body before being broken down represent a key difference between fluoxetine and paroxetine paroxetine is broken down after about a day in most people whereas fluoxetine remains for about one to three days this difference has functional significance because when doctors are weaning

Patients off of an ssri they prefer to use one with a longer half-life to minimize withdrawal effects a person taking paroxetine may be switched to fluoxetine by a doctor as they taper their dose down in order to avoid withdrawal side effects that occur from taking fluoxetine and paroxetine are quite similar there are some small differences in the incidence rates

Of individual side effects however patients taking fluoxetine tend to report slightly more incidence of insomnia and loss of appetite but those taking paroxetine show higher rates of nausea and somnolence or drowsiness studies that have investigated the efficacy and side effect rates show that both of these drugs are well tolerated by most people however and that

The side effects do not impact their usefulness

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What Are the Differences between Fluoxetine and Paroxetine By all about bengal