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Allopurinol reduces the production of uric acid in the body uric acid buildup can lead to gouter kidney stones allopurinol is used to treat gouter kidney stones allopurinol is also used to decrease levels of uric acid in people who are receiving cancer treatment allopurinol car therapy is used to improve outcomes for people with inflammatory bowel disease and
Crohn’s disease who do not respond to thiopurine monotherapy usual adult dose of allopurinol for goutas dose will vary with the severity of the disease initial dose is 100 milligrams orally once a day increase in increments of 100 milligrams weekly until a serum uric level of 6 milligrams per deciliter or less as attained in mild gout the average maintenance
Dose is 200 to 300 milligrams orally once a day in moderately severe to fascia scout the average maintenance dose 400 to 600 milligrams orally per day in divided doses minimal effective dose is 100 to 200 milligrams per day maximum dose is 800 milligrams per day usual adult dose of allopurinol for hyperuricemia secondary to chemotherapy is for parenteral 200
To 400 milligrams per meter two per day’s iv is a single infusion or an equally divided infusions at 6 8 or 12 hour intervals as maximum dose 600 milligrams per day for oral as initial dose 600 to 800 milligrams orally in divided doses maintenance is adjust doses needed based on serum uric acid levels maximum dose is 800 milligrams per day usual adult dose of
Allopurinol for calcium oxalate calculi with hyperuricosuria is 200 to 300 milligrams orally once a day or in divided doses usual pediatric dose for hyperuricemia secondary to chemotherapy is for parenteral initial dose is 200 milligrams per meter two per day’s iv is a single infusion or in equally divided infusions at 6 8 or 12 hour intervals maximum dose
Is 600 milligrams per day for oral age less than six years is 150 milligrams orally once a day or in divided doses for age 6 to 10 years 300 milligrams orally once a day or in divided doses for age greater than 10 years 600 to 800 milligrams orally per day in divided doses after 48 hours evaluate and adjust doses needed allopurinol is a structural analog
Of the natural purine base hypoxanthine after ingestion allopurinol is metabolized to its active metabolite oxypurinol aloxanthine in the liver which acts as an inhibitor of xanthine oxidase enzyme allopurinol and its active metabolite inhibits xanthine oxidase the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid inhibition of this
Enzyme is responsible for the effects of allopurinol this drug increases the reutilization of hypoxanthine and xanthine for nucleotide and nucleic acid synthesis by a process that involves the enzyme hypoxanthine guanine phosphorivocil transferase hgpr tase this process results in an increased nucleotide concentration which causes feedback inhibition of de
Novo purine synthesis the end result is decreased urine and serum uric acid concentrations which decreases the incidence of gout symptoms accompanying the reduction of serum uric acid by allopurinol is an increase in the serum and urine concentrations of hypoxanthine and xanthine due to inhibition of xanthine oxidase in the absence of allopurinol regular
Urinary excretion of oxypurines almost entirely occurs in the form of uric acid after the ingestion of allopurinol the contents of excreted urine are hypoxanthine xanthine and uric acid because each substance has its own individual solubility the concentration of uric acid and plasma is decreased without exposing the renal tissues to a high load of uric
Acid thereby decreasing the risk of crystalluria by lowering the uric acid concentration in the plasma below its limits of solubility allopurinol encourages the dissolution of gautopi although the levels of hypoxanthine and xanthine are found to be increased after allopurinol ingestion the risk of deposition in renal tissues is less than that of uric acid
As they become more soluble and are rapidly excreted by the kidney some severe side effects are skin rash painful urination blood in the urine little or no urination easy bruising unusual bleeding numbness tingling burning pain worsening gout symptoms or liver problems consult doctor if any of these side effects occurs common allopurinol side effects are an
Increase in gout attacks when you first starting taking allopurinol oral rash drowsiness fever chills abnormal liver function tests nausea diarrhea or joint pain caution is advised when consuming alcohol with allopurinol please consult your doctor allopurinol may be unsafe to use during pregnancy although there are limited studies in humans animal studies
Have shown harmful effects on the developing baby your doctor will weigh the benefits and any potential risks before prescribing it to you please consult your doctor allopurinol is safe to use during breastfeeding human studies suggest that the drug does not pass into the breast milk in a significant amount and is not harmful to the baby allopurinol should
Be used with caution in patients with kidney disease dose adjustment of allopuranol may be needed please consult your doctor allopurinol may cause side effects which could affect your ability to drive occasionally drowsiness dizziness or vertigo ataxia and visual disturbances may occur when taking allopurinol this may affect your driving ability allopurinol
Should be used with caution in patients with liver disease dose adjustment of allopurinol may be needed please consult your doctor you
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What is Allopurinol ? Allopurinol Uses | Dosages, Mechanism of action and side effect of Allopurinol By Know Your Drug
