December 8, 2022

Generic Name: Rosuvastatin calcium

Hello welcome to my channel subscribe or like if you like it today we are going to talk about the medicine rosuvastatin with brand name prestor we will explain its mechanism of action side effects dosage uses contraindications warnings pregnancy and indications what is rosuvastatin and how does it work rosuvastatin is used along with a proper diet to help lower

Bad cholesterol and fats such as ldl triglycerides and raise good cholesterol hdl in the blood it belongs to a group of drugs known as statins it works by reducing the amount of cholesterol made by the liver lowering bad cholesterol and triglycerides and raising good cholesterol decreases the risk of heart disease and helps to prevent strokes and heart attacks in

Addition to eating a proper diet such as a low cholesterol slash low fat diet other lifestyle changes that may help rosuvastatin work better include exercising losing weight if overweight and stopping smoking talk with your doctor for more details rosuvastatin is available under the following different brand names crestor dosages of rosuvastatin adult and pediatric

Dosage forms and strengths 5 milligrams 10 milligrams 20 milligrams 40 milligrams dosage considerations should be given as follows hypercholesterolemia hypertriglyceridemia hyperlipidemia mixed dyslipidemia slowing progression of atherosclerosis primary dispatalipoprotinemia 10 to 20 milligrams orally once slash day initially may titrate not to exceed 40

Milligrams slash day dosage range 5 to 40 milligrams slash day homozygous familial hypercholesterolemia initiate with 20 milligrams orally once slash day may titrate not to exceed 40 milligrams slash day heterozygous familial hypercholesterolemia efh indicated to reduce total c ldlc and a pod levels in children and adolescents aged 8 to 17 years if after an

Adequate trial of diet therapy the following findings are present ldlc greater than 190 milligrams slash deal or greater than 160 milligrams slash deal along with a positive family history of premature cardiovascular disease cvd or two cardiovascular disease or more risk factors children under eight years safety and efficacy not established children ate to under

10 years 5 to 10 milligrams orally once slash day children 10 to 17 years 5 to 20 milligrams orally once slash day may adjust dose at intervals of at least four weeks not to exceed 20 milligrams slash day homozygous familial hypercholesterolemia ofh indicated to reduce ldlc total c non-tlc and a pob in children and adolescents aged 7 to 17 years with homozygous

Familial hypercholesterolemia either alone or with other lipid lowering treatments for example ldl apheresis children under seven years safety and efficacy not established children 7 to 17 years 20 milligrams orally once slash day primary prevention primary prevention of cardiovascular disease in individuals with no clinically evident heart disease but who are at

Risk because of combined effect of risk factors listed below approval based on jupiter trial justification for the use of statins in prevention an intervention trial evaluation resuvvist at an initial 10 to 20 milligrams orally once slash day dosage range 5 to 40 milligrams slash day cardiovascular disease shown to reduce risk of stroke heart attack myocardial

Infarction me and arterial revascularization procedures including coronary artery bypass graft cab bypass grafting of peripheral artery or carotid artery and angioplasty or stent placement risk factors age over 50 years in men over 60 years in women and elevated high sensitivity c reactive protein level greater than two milligrams slash l and presence of at least

One additional cardiovascular risk factor for example high blood pressure low hdlc smoking family history of premature heart disease dosing considerations patients of asian descent initiate with five milligrams slash day co-administration with other lipid lowering therapy consider dose reduction if combined with niacin or phenofibrate because of increased risk for

Skeletal muscle effects co-administration with cyclosporine not to exceed five milligrams slash day co-administration with gemfi brazil a void if possible if used together do not exceed 10 milligrams slash day co-administration with reitonavir lopinovir slash rytonovir or atazanovir rytonovir not to exceed 10 milligrams slash day overdose management adverse drug

Reactions from overdose may include peripheral neuropathy diarrhea increased potassium myopathy rhabdomyolysis acute renal failure elevated liver function tests lfds eye lens opacities treatment is supportive dosing modifications renal impairment severe crcl less than 30 milliliters per minute slash 1.73 square meters and not on hemodialysis decrease starting dose

To 5 milligrams early once slash day not to exceed 10 milligrams orally once slash day crcl greater than 30 milliliters per minute slash 1.73 square meters dose adjustment not necessary active liver disease uses contraindicated chronic alcoholic liver disease is known to increase rosuvastatin exposure caution advised what is side effects drug interactions warning

And precautions brand name crestor generic name rosuvastatin drug class lipid lowering agents statins hmg co-reductase inhibitors what is rosuvastatin and how does it work rosuvastatin is used along with a proper diet to help lower bad cholesterol and fats such as ldl triglycerides and raise good cholesterol hdl in the blood it belongs to a group of drugs known

As statins it works by reducing the amount of cholesterol made by the liver lowering bad cholesterol and triglycerides and raising good cholesterol decreases the risk of heart disease and helps to prevent strokes and heart attacks in addition to eating a proper diet such as a low cholesterol slash low fat diet other lifestyle changes that may help rosuvastatin

Work better include exercising losing weight if overweight and stopping smoking talk with your doctor for more details rosuvastatin is available under the following different brand names crestor dosages of rosuvastatin adult and pediatric dosage forms and strengths 5 milligrams 10 milligrams 20 milligrams 40 milligrams dosage considerations should be given as

Follows hypercholesterolemia hypertriglyceridemia hyperlipidemia mixtus lipidemia slowing progression of atherosclerosis primary dispatalipoprotinemia 10 to 20 milligrams orally once slash day initially may titrate not to exceed 40 milligrams slash day dosage range 5 to 40 milligrams slash day homozygous familial hypercholesterolemia initiate with 20 milligrams

Orally once slash day may titrate not to exceed 40 milligrams slash day heterozygous familial hypercholesterolemia efh indicated to reduce total c ldlc and a pod levels in children and adolescents aged 8 to 17 years if after an adequate trial of diet therapy the following findings are present ldlc greater than 190 milligrams slash deal or greater than 160

Milligrams slash deal along with a positive family history of premature cardiovascular disease cvd or two cardiovascular disease or more risk factors children under eight years safety and efficacy not established children ate to under 10 years 5 to 10 milligrams orally one slash day children 10 to 17 years 5 to 20 milligrams orally once slash day may adjust dose

At intervals of at least four weeks not to exceed 20 milligrams slash day homozygous familial hypercholesterolemia ofh indicated to reduce ldl c total c non tlc and a pob in children and adolescents aged 7 to 17 years with homozygous familial hypercholesterolemia either alone or with other lipid lowering treatments for example ldl apheresis children under seven

Years safety and efficacy not established children 7 to 17 years 20 milligrams orally once slash day primary prevention primary prevention of cardiovascular disease in individuals with no clinically evident heart disease but who are at risk because of combined effective risk factors listed below approval based on jupiter trial justification for the use of statins

In prevention an intervention trial evaluation receivastat an initial 10 to 20 milligrams orally once slash day dosage range 5 to 40 milligrams slash day cardiovascular disease shown to reduce risk of stroke heart attack myocardial infarction me and arterial revascularization procedures including coronary artery bypass graft cab bypass grafting of peripheral artery

Or carotid artery and angioplasty or stent placement risk factors age over 50 years in men over 60 years in women and elevated high sensitivity c reactive protein level greater than two milligrams l and presence of at least one additional cardiovascular risk factor for example high blood pressure low hdlc smoking family history of premature heart disease dosing

Considerations patients of asian descent initiate with five milligrams slash day co-administration with other lipid lowering therapy consider dose reduction if combined with niacin or phenofibrate because of increased risk for skeletal muscle effects co-administration with cyclosporin not to exceed five milligrams slash day co-administration with gemfi brazil avoid

If possible if used together do not exceed 10 milligrams slash day co-administration with reitonavir lopinovir slash rytonovir or atazanovir rytonovir not to exceed 10 milligrams slash day overdose management adverse drug reactions from overdose may include peripheral neuropathy diarrhea increased potassium myopathy rhabdomyolysis acute renal failure elevated

Liver function tests lfds eye lens opacities treatment is supportive dosing modifications renal impairment severe crcl less than 30 milliliters per minute slash 1.73 square meters and not on hemodialysis decrease starting dose to five milligrams early once slash day not to exceed 10 milligrams orally once slash day crcl greater than 30 milliliters per minute

Slash 1.73 square meters dose adjustment not necessary active liver disease use is contraindicated chronic alcoholic liver disease is known to increase rosuvastatin exposure caution advised slideshow how to lower your cholesterol and save your heart see slideshow what are side effects associated with using rosuvastatin common side effects of rosuvastatin

Include muscle pain joint pain diabetes mellitus new onset sore throat headache weakness lack of energy dizziness creatine phospho canaz cpk increased nausea abdominal pain alanine transaminase alt increased constipation flu-like illness urinary tract infection uti hypersensitivity reactions including rash itching hives and swelling pancreatitis less

Common side effects of rosuvastatin include yellowing skin and eyes jaundice muscle disease muscle wasting rhabdomyolysis post-marketing side effects of rosuvastatin reported include joint pain numbness slash tingling slash pain in extremities depression and sleep disorders including insomnia nightmares fatal and non-fatal hepatic failure hepatitis jaundice low

Blood platelet count thrombocytopenia breast tissue enlargement in males this is not a complete list of side effects and other serious side effects may occur call your doctor for information and medical advice about side effects you may report side effects to fda at one to 800 fda 1088 what other drugs interact with rosuvastatin if your doctor has directed you

To use this medication your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them do not start stop or change the dosage of any medicine before checking with your doctor healthcare provider or pharmacist first severe interactions of rosuvastatin include gemfibrazil red yeast rice serious interactions of

Rosuvastatin include atoxanovir clarithromycin colchicine cyclosporinel trombopag pheno fibrate phenofibrate micronized phenofibric acid gem fibrozolendinovir ketoconazole adipose slash phosphavir lopinovir mifapristo nelfinavir niacin on bitosphere slash parita previtonavir and desabi viraitonavir sequinovirosuvastatin has moderate interactions with at least 46

Different drugs mild interactions of rosuvastatin include coenzyme q10 cholesterol erythromycin base erythromycin ethyl succinate erythromycin lactobionate erythromycin stearate ethenyl strateal isrotapine mestrinol orlistat tracidone this document does not contain all possible interactions therefore before using this product tell your doctor or pharmacist

Of all the products you use keep a list of all your medications with you and share the list with your doctor and pharmacist check with your physician if you have health questions or concerns what are warnings and precautions for rosuvastatin warnings this medication contains rosuvastatin do not take crest or if you are allergic to rosuvastatin or any ingredients

Contained in this drug keep out of reach of children in case of overdose get medical help or contact a poison control center immediately contraindication hypersensitivity active liver disease elevated liver function tests lfd’s pregnancy lactation effects of drug abuse none short-term effects see what are side effects associated with using rosuvastatin long-term

Effects see what are side effects associated with using rosuvastatin cautions non-serious and reversible cognitive side effects may occur increased blood sugar and glycosylated hemoglobin a1c levels reported with statin intake in some instances these increases may exceed the threshold for the diagnosis of diabetes mellitus chronic liver disease measure liver

Enzymes before initiating and if signs or symptoms of liver injury occur consider lower initial dose 5 milligrams once slash day in patients with risk of myopathy increased risk of rhabdomyolysis especially at highest approved dose of 40 milligrams slash day reserve highest dose only for patients who fail to achieve desired cholesterol level at 20 milligrams slash

Day use 5 milligrams slash day starting dose in people of asian ancestry who may build up higher drug levels and be at higher risk of myopathy rare reports of immune-mediated necrotizing myopathy imnm characterized by increased serum creatine kinase that persists despite discontinuing statin discontinue if creatine kinase ck levels are markedly elevated pregnancy

And lactation rosuvastatin is contraindicated for use during pregnancy because hmg co-reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol for example cell membranes rosuvastatin may cause fetal harm when administered to pregnant women rosuvastatin is contraindicated for

Use while breastfeeding limited data indicate that rosuvastatin is present in human milk because statins have the potential for serious adverse reactions in nursing infants women who require rosuvastatin treatment should not prestige their infants

Transcribed from video
What is ROSUVASTATIN (Crestor), how does it work?. Dosage, Side effects and uses of rosuvastatin By Medicines/Diseases